Results 91 to 100 of about 68,019 (287)

Quantifying discrepancies in opinion spectra from online and offline networks

, 2015
Online social media such as Twitter are widely used for mining public opinions and sentiments on various issues and topics. The sheer volume of the data generated and the eager adoption by the online-savvy public are helping to raise the profile of ...
Hahn, Kyu S., Lee, Deokjae, Park, Juyong, Yook, Soon-Hyung   +3 more
core   +3 more sources

Separation of powers, partisanship and impeachment: How can we overcome the partisan propaganda? [PDF]

, 2020
[excerpt] Our Constitutional system divides power horizontally, among the three branches of the federal government, and vertically, between the federal government and the states.
Greabe, John M
core   +1 more source

Mayoral Partisanship and the Size of Municipal Government [PDF]

, 2016
Does it matter for municipal policy which party controls the mayorship in municipal government? The bulk of the existing evidence says no. But there are a variety of theoretical reasons to believe that mayoral partisanship should affect municipal policy.
De Benedictis-Kessner, Justin, Warshaw, Christopher S   +1 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Türkiye’de Duygusal Kutuplaşma ve Oy Verme İlişkisi

Alternatif Politika
Bu çalışma, Türkiye’de 2011, 2015 ve 2018 genel seçimlerinden sonra yapılan seçim sonrası anketlerinden yararlanarak seçmenlerin duygusal kutuplaşma düzeylerini ve bu kutuplaşmanın oy kullanma yolu ile siyasi katılıma etkilerini incelemektedir.
Seda Çalışır
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Does Ignorance Matter? The Relative Importance of Civic Knowledge and the Human Tendency to Engage in Motivated Reasoning

Journal of Public and Nonprofit Affairs, 2015
It has long been understood that political knowledge in the U.S. is very low. For those who care about the quality of American democracy, this is a big problem. In attempting to find a solution, many people often blame education.
Aaron Dusso, Sheila Suess Kennedy
doaj   +1 more source

Institutions, Information, and Trade Policy in Times of Crisis [PDF]

, 2011
The paper examines the role of international institutions in preventing the rise of protectionism in times of times of crisis. Economic crisis exacerbates uncertainty in the conduct of commercial relations and thus makes it more likely for countries to ...
Baccini, Leonardo, Kim, Soo Yeon
core  

When Church Teachings and Policy Commitments Collide: Perspectives on Catholics in the U.S. House of Representatives [PDF]

, 2008
This article investigates the influence of religious values on domestic social policy-making, with a particular focus on Catholics. We analyze roll call votes in the 109th Congress and find that Catholic identification is associated with support for ...
Hudson, William E., Oldmixon, Elizabeth A.   +1 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source