Results 71 to 80 of about 3,394 (264)

Partisan polarization, populist attitudes, and anti-democratic behaviors

open access: yesFrontiers in Political Science
IntroductionOn December 3, 2024, South Korean President Yoon Suk Yeol briefly declared martial law, triggering a four-month constitutional crisis that culminated in his impeachment by the Constitutional Court.
Miongsei Kang, Jong-Cheol Kim
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

A theory of dual partisanship

open access: yes, 2007
In this paper we contrast two approaches of conceptualising and operationalising partisanship. The first defines partisanship as a social identity, following the original conceptualisation by the Michigan scholars. The second defines partisanship as a configuration of attitudes or party evaluations.
Rosema, Martin, Thomassen, Jacques
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Partisan Selective Exposure in Times of Political and Technological Upheaval: A Social Media Field Experiment

open access: yesMedia and Communication, 2019
Contemporary democracies are increasingly shaped by a surge of populism, posing serious threats to the idea of liberal democracy. Particularly in the run-up to elections, knowledge of such threats is essential for citizens to cast an informed vote ...
Cornelia Mothes, Jakob Ohme
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Unearthing the mediating role of political affiliation in tax compliance determinants: new evidence from Ghana

open access: yesCogent Business & Management
This study investigates the moderating role of political party affiliation in the relationship between tax knowledge, service quality, and tax compliance.
George Nyantakyi   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Behavioral science of voting in hypothetical utopia and dystopia scenarios: a predictive modeling approach

open access: yesFrontiers in Psychology
We investigated how near-future utopia and dystopia scenarios affect electorates' valuation of the leading Finnish politicians in the multiparty democracy.
Janne Kauttonen, Jyrki Suomala
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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