Results 51 to 60 of about 3,501 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

How do drivers react to partisan bumper stickers? Understanding polarization in apolitical settings

Frontiers in Political Science
IntroductionThe impact of political polarization is no longer confined to the voting booth, and partisan identity can shape behavior even in seemingly apolitical spaces. In this paper we investigate whether something as simple as seeing a partisan bumper
Rachel Suzanne Torres, Benjamin David Farrer   +1 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Political Identity Convergence: On Being Latino, Becoming a Democrat, and Getting Active

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2016
The majority of Latinos in the United States identify with the Democratic Party, a tendency with broad political implications as Latinos become an increasingly large segment of the population. Little research, however, has delved into the origins of this
Leonie Huddy, Lilliana Mason, S. Nechama Horwitz   +2 more
doaj   +1 more source

Partisanship Creep

SSRN Electronic Journal, 2023
It was once well settled and uncontroversial—reflected in legislative enactments, Executive Branch practice, judicial doctrine, and the broader constitutional culture—that the Constitution imposed limits on government partisanship. This principle was one instantiation of a broader set of rule of law principles: that law is not merely an instrument ...
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Partisanship and Risk Talk on Twitter

Journal of Quantitative Description: Digital Media
There is abundant evidence that political polarization is associated with perceptions, beliefs, and behaviors related to the COVID-19 pandemic. This article turns to online expression and investigates the prominence, targets, and drivers of risk talk ...
Yini Zhang, Jody CS Wong, Zijian An, Maximilian Brimmer, Kenneth Joseph, Janet Yang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Türkiye’de Duygusal Kutuplaşma ve Oy Verme İlişkisi

Alternatif Politika
Bu çalışma, Türkiye’de 2011, 2015 ve 2018 genel seçimlerinden sonra yapılan seçim sonrası anketlerinden yararlanarak seçmenlerin duygusal kutuplaşma düzeylerini ve bu kutuplaşmanın oy kullanma yolu ile siyasi katılıma etkilerini incelemektedir.
Seda Çalışır
doaj   +1 more source

COVID-19 and the Culture of American Federalism

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2022
COVID-19 highlighted America’s federalist structure as the dissemination of pandemic information was frequently left to states and localities. For some citizens, this was a welcome relief from national-level policymaking and political narratives, though ...
Emily Pears, Emily Sydnor
doaj   +1 more source