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Partition coefficients of acyclic graphs
1995We develop the concept of a “closure space”; which appears with different names in many aspects of graph theory. We show that acyclic graphs can be almost characterized by the partition coefficients of their associated closure spaces. The resulting nearly total ordering of all acyclic graphs (or partial orders) provides an effective isomorphism filter ...
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Electrochemical Determination of Partition Coefficients of Drugs
Journal of Pharmaceutical Sciences, 1992An electrochemical method for the determination of partition coefficients of drugs that can exist as ions in aqueous solutions is presented. The method involves cyclic voltammetry at the polarizable interface between two immiscible electrolyte solutions.
K, Kontturi, L, Murtomäki
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Liquid/Air Partition Coefficients of the Trimethylbenzenes
Toxicology and Industrial Health, 1995Liquidlair partition coefficients (λ) of the three isomers of trimethylbenzene (1,2,3-, 1,2,4-, and 1,3,5-TMB) were determined in vitro using automated head space gas chromatography. The liquids used were water (physiological saline), fresh human blood, and olive oil.
J, Järnberg, G, Johanson
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Partition Coefficients for Benzene in Human Skin
AIHAJ, 2002The contribution of benzene to body burden after skin absorption compared with that due to inhalation absorption is of potential interest in the setting and interpretation of benzene (inhalation) exposure standards. However, an understanding of the quantitative relationship between skin and inhalation absorption, under different exposure conditions, is
Georgia C, Sinclair +2 more
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The influence of hydrogen bonding on partition coefficients
Journal of Computer-Aided Molecular Design, 2017This Perspective explores how consideration of hydrogen bonding can be used to both predict and better understand partition coefficients. It is shown how polarity of both compounds and substructures can be estimated from measured alkane/water partition coefficients.
Nádia Melo Borges +6 more
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Selected noble-gas partition coefficients
Physics in Medicine and Biology, 1985The Ostwald solubility of 41Ar, 127,133Xe, N13N and CH3 18F in water, saline, blood, plasma, lipids, benzene and bone were measured in vitro. In addition the bone-blood partition coefficients for these gases were determined. For 41Ar, the bone-blood partition function is found to be 1.1 +/- 0.3, whereas for xenon the bone-blood partition coefficient is
M S, Rosenthal, R J, Nickles
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Partition Coefficients of Three New Anticonvulsants
Journal of Pharmaceutical Sciences, 1990The partition coefficients of three homologous anticonvulsant phenylalkylamides [racemic alpha-hydroxy-alpha-ethyl-alpha-phenylacetamide (HEPA); beta-hydroxy-beta-ethyl-beta-phenylpropionamide (HEPP); and gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide (HEPB)] were determined by reversed-phase high-performance liquid chromatography (RP-HPLC).
Z, Hernandez-Gallegos, P A, Lehmann
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MembraneiBuffer Partition Coefficient for Ethanol in Dimyristoylphosphatidylcholine
Alcoholism: Clinical and Experimental Research, 1981Phase transitions of dimyristoylphosphatidylcholine (DMPC) are followed using optical density measurements, as a function of aqueous ethanol concentration. The shift of the phase transition to lower temperatures is interpreted in terms of the thermodynamics of freezing point depressions.
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An analysis of robustness of partition coefficient index
2008 IEEE International Conference on Fuzzy Systems (IEEE World Congress on Computational Intelligence), 2008We know that the partition coefficient index has the monotonic tendency with cluster number c. Moreover, they always select the smallest cluster number c=2 as a optimal cluster number estimate when data contains some noise points. In this paper, we will discuss this problem by defining the validity measure of each single data point.
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Relationships Among Activity Coefficients, Partition Coefficients and Solubilities
1976The partition coefficient of a compound in a partitioning system of two liquid phases is the most frequently used characteristics for structure-activity relationships. Thanks to Hansch and his co-workers, partition coefficients of compounds in the octanol/water system have become universally and very successfully used [1].
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