Results 61 to 70 of about 75,572 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Factorization of rational six vertex model partition functions

Nuclear Physics B
We show factorization formulas for a class of partition functions of rational six vertex model. First we show factorization formulas for partition functions under triangular boundary.
Kohei Motegi
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Higher rank elliptic partition functions and multisymmetric elliptic functions

Nuclear Physics B
We introduce and investigate a class of glM+1 partition functions which is an extension of the one introduced by Foda-Manabe. We characterize the partition functions by a nested version of Izergin-Korepin analysis, and determine the explicit forms, for ...
Allan John Gerrard, Kohei Motegi, Kazumitsu Sakai   +2 more
doaj   +1 more source

Anomalous dimensions from thermal AdS partition functions

Journal of High Energy Physics, 2020
We develop an efficient method for computing thermal partition functions of weakly coupled scalar fields in AdS. We consider quartic contact interactions and show how to evaluate the relevant two-loop vacuum diagrams without performing any explicit AdS ...
Per Kraus, Stathis Megas, Allic Sivaramakrishnan   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Almost Everywhere Behavior of Functions According to Partition Measures

Forum of Mathematics, Sigma
This paper will study almost everywhere behaviors of functions on partition spaces of cardinals possessing suitable partition properties. Almost everywhere continuity and monotonicity properties for functions on partition spaces will be established ...
William Chan, Stephen Jackson, Nam Trang
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Super Rogers–Szegö polynomials associated with BCN type of Polychronakos spin chains

Nuclear Physics B, 2017
As is well known, multivariate Rogers–Szegö polynomials are closely connected with the partition functions of the AN−1 type of Polychronakos spin chains having long-range interactions. Applying the ‘freezing trick’, here we derive the partition functions
B. Basu-Mallick, C. Datta
doaj   +1 more source