Results 191 to 200 of about 5,964 (241)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

A fuzzy based chicken swarm optimization algorithm for efficient fault node detection in Wireless Sensor Networks. [PDF]

Sci Rep
Nagarajan B, Svn SK, Selvi M, Thangaramya K.   +3 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Effect of Temperature Gradient and Cooling Rate on the Solidification of Iron: A Molecular Dynamics Study. [PDF]

Materials (Basel)
Qin Q, Li W, Wang W, Li D, Xie L.
europepmc   +1 more source

Cell4D: a general purpose spatial stochastic simulator for cellular pathways. [PDF]

BMC Bioinformatics
Chan D, Cromar GL, Taj B, Parkinson J.
europepmc   +1 more source

A privacy-protecting eggplant disease detection framework based on the YOLOv11n-12D model. [PDF]

Front Plant Sci
Han J, Wu Z, Ding Y, Guo Y, Fu R.
europepmc   +1 more source

The Parameter Calibration of Social Force Model for Pedestrian Flow Simulation Based on YOLOv5. [PDF]

Sensors (Basel)
Li T, Xu B, Lu W, Chen Z, Zhang S, Xia F.   +5 more
europepmc   +1 more source

Elementary Triangular Partitioned Cellular Automata (Frontiers of Theoretical Computer Science)

Elementary Triangular Partitioned Cellular Automata (Frontiers of Theoretical Computer Science)
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Coupling cellular automata with area partitioning and spatiotemporal convolution for dynamic land use change simulation

Science of The Total Environment, 2020
Urbanization processes have accelerated over recent decades, prompting efforts to model land use change (LUC) patterns for decision support and urban planning. Cellular automata (CA) are extensively employed given their simplicity, flexibility, and intuitiveness when simulating dynamic LUC.
Yuehui Qian, Weiran Xing, Xuefeng Guan, Tingting Yang, Huayi Wu   +4 more
openaire   +4 more sources