Results 151 to 160 of about 2,205 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Vene ja eesti üliõpilaste valikud täis- ja osasihitise kasutamisel
Lähivõrdlusi, 2010 The article compares the use of total and partial objects by L2 and L1 speakers of Estonian. For the purposes of the article, L2 speakers of Estonian are native speakers of Russian who are pursuing a programme of studies in Estonian as a foreign language
Raili Pool
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Discrete Mathematics, 2000 Tverberg's theorem says that every set of \((m-1)(d+1)+1\) points in \(\mathbb{R}^d\) can be divided into \(m\) subsets whose convex hulls have a common point. The case \(m=2\) is known as Radon's theorem. Generalization to arbitrary convexity spaces leads to the partition conjecture. This paper gives a survey on known results and proves the conjecture
openaire +2 more sources
Genesis of the Genitive of Negation in Balto-Slavic and Its Evidence in Contemporary Slovenian
Slovenski Jezik - Slovene Linguistic Studies, 2019 Genitive of negation is a Balto-Slavic syntactic rule that governs the transformation of accusative complements of transitive verbs or subjects of existential constructions in positive sentences to genitive complements in negative sentences.
Žiga Pirnat
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Language and the Moving Body: Directive Actions With the Finnish kato "look" in Nature-Related Activities. [PDF]
Front Psychol, 2021 Siitonen P, Rauniomaa M, Keisanen T.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source