Results 61 to 70 of about 523,125 (295)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Experimental data exploring the effects of intranasal oxytocin on young adult social preference and attachment to romantic partners, parents, friends, and strangers

Data in Brief, 2022
Experimental studies exploring the effects of intranasal oxytocin are typically underpowered due to small samples. Open access to experimental data and procedures and the use of previously employed measures is critical to building more robust and ...
Harry Freeman, Jamie L. Scholl, Musheera AnisAbdellatif, Gina L. Forster, Suma Jacob, Sabi Kaflay, Rajeev Bam, Tuyen Do, Etienne Z. Gnimpieba   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Investigating Women's Preference for Sildenafil or Tadalafil Use by Their Partners with Erectile Dysfunction: The Partners' Preference Study

The Journal of Sexual Medicine, 2008
Abstract Introduction Several preference studies comparing a short-acting with a longer-acting phosphodiesterase type 5 inhibitor have been conducted in men. Most men in those studies preferred tadalafil rather than sildenafil, and recent post hoc analysis of one study described several factors ...
Helen M, Conaglen, John V, Conaglen
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Do Impressions of Health, Dominance, and Warmth Explain Why Masculine Faces are Preferred More in a Short-Term Mate?

Evolutionary Psychology, 2007
Men high in facial masculinity are preferred more as a short-term partner (STP) than a long-term partner (LTP). We used a representative sample of natural faces to examine whether the greater preference for masculine-looking men as a STP could be ...
Victor X. Luevano, Leslie A. Zebrowitz
doaj   +1 more source

Preference for Male Facial Masculinity as a Function of Mental Rotation Ability in Gay and Bisexual Men, but Not in Heterosexual Men and Women in China

Frontiers in Psychology, 2019
This study examined the association between mental rotation ability and facial masculinity preference in gay and bisexual men in China. The participants (436 gay/bisexual men, 132 heterosexual men, and 254 heterosexual women) completed an online Shepard ...
Lijun Zheng
doaj   +1 more source

Design of a randomized superiority trial of a brief couple treatment for PTSD. [PDF]

, 2019
Interpersonal difficulties are common among veterans with posttraumatic stress disorder (PTSD) and are associated with poorer treatment response. Treatment outcomes for PTSD, including relationship functioning, improve when partners are included and ...
Becker, Julia, Buzzella, Brian, Glassman, Lisa H, Glynn, Shirley, Grubbs, Kathleen M, Macdonald, Alexandra, Mackintosh, Margaret-Anne, Monson, Candice M, Morland, Leslie A, Rooney, Benjamin M, Sautter, Frederic, Wells, Stephanie Y, Wrape, Elizabeth   +12 more
core   +1 more source

Simulation-based mentalizing generates a ‘proxy’ self-reference effect in memory [PDF]

, 2016
The self-reference effect (SRE) in memory is thought to depend on specialized mechanisms that enhance memory for self-relevant information. We investigated whether these mechanisms can be engaged “by proxy” when we simulate other people, by asking ...
Allan, Kevin, Cunningham, Sheila J., Dixon, Susan, Martin, Douglas, Morson, Suzannah   +4 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source