Results 71 to 80 of about 523,125 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Pro-social preference in an automated operant two-choice reward task under different housing conditions: Exploratory studies on pro-social decision making

Developmental Cognitive Neuroscience, 2020
In this study, we aimed to develop a behavioral task that measures pro-social decision making in rats. A fully automated, operant pro-social two-choice task is introduced that quantifies pro-social preferences for a mutual food reward in a set-up with ...
Jiska Kentrop, Aikaterini Kalamari, Chiara Hinna Danesi, John J. Kentrop, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joëls, Rixt van der Veen   +7 more
doaj   +1 more source

Is Ageism Alive in Date Selection Among Men? Age Requests Among Gay and Straight Men in Internet Personal Ads

, 2003
We examine 2,400 personal ads from male advertisers collected from the Internet, focusing on age preference by race and sexual orientation. We look at whether advertisers display any age preference in personal ads and whether the preference varies by ...
Kaufman, Gayle, Phua, VoonChin
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Construction of individual-specific social cognitive maps in the human brain

Cell Reports
Summary: Social interactions depend on social cognitive maps (SCMs) in the brain. We investigate how SCMs emerge during partner selection based on trial-by-trial feedback about candidates’ generosity and competence. We show that the candidates spread out
Tianyu Gao, Yiwen Deng, Shihui Han
doaj   +1 more source

Perinatale programmering van volwassen seksueel gedrag en partner preferentie van de rat [PDF]

, 1991
Aims of the present study 1. Is adulttestosterone-induced mounting behavior of female rats organized by perinatally circulating testosterone (T)? 2. What role does the prenatal position in utero relative to a brother play in this respect? 3.
Brand, T. (Teus)
core   +1 more source

On preferences over subsets and the lattice structure of stable matchings [PDF]

, 2001
This paper studies the structure of stable multipartner matchings in two-sided markets where choice functions are quotafilling in the sense that they satisfy the substitutability axiom and, in addition, fill a quota whenever possible. It is shown that
Alkan, Ahmet
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Leadership Status, Sexual Harassment Training, and Women’s Expectations About Working with Men

Social Sciences
Background: Occupational gender segregation is a key driver of labor market inequality and is prominent across occupations, within occupations, and within workplace task groups.
Justine E. Tinkler, Jody Clay-Warner
doaj   +1 more source

Women have a preference for their male partner to be HPV vaccinated. [PDF]

PLoS ONE, 2014
BACKGROUND:Peer influence and social networking can change female adolescent and young adult behavior. Peer influence on preferences for male human papillomavirus (HPV) vaccination has not been documented.
Diane Medved Harper, Natalie Marya Alexander, Debra Ann Ahern, Johanna Claire Comes, Melissa Smith Smith, Melinda Ann Heutinck, Sandra Martin Handley   +6 more
doaj   +1 more source