Results 91 to 100 of about 392,884 (306)

Enhancing Rural Science Education through School District–University Partnership

Education Sciences
This instrumental case study describes the steps taken to establish and implement a university–school partnership to improve rural science teachers’ content knowledge and teaching practices and students’ achievement in elementary science and high school ...
Venicia A. Ferrell, Alexis S. Tharpe
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Efficient public-private partnerships [PDF]

This paper presents a model to assess the efficiency of the capital structure in public-private partnerships (PPP). A main argument supporting the PPP approach to investment projects is the transfer of managerial skills and know-how from the private ...
Moszoro, Marian
core  

283 Progress in Community Health Partnerships Writing, Dissemination and Reviewer Learning Community for Community-Patient Authors and Reviewers (henceforth, PCHP LC)

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: The peer-reviewed journal Progress in Community Health Partnerships (PCHP) promotes health research partnerships to improve community health.
Karen Calhoun, Tabia Akintobi, Al Richmond, N Glassman, Rosanna Barrett, Hal Strelnick   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

EU cyber partnerships: Assessing the EU strategic partnerships with third countries in the cyber domain. Egmont Paper, 20 February 2018 [PDF]

, 2018
The European Union is increasingly active on cyber issues internationally, guided by its various foreign policy documents and strategies, including its 2013 Cybersecurity Strategy and the 2015 Council conclusions on cyber-diplomacy.
Renard, Thomas
core  

Competitiveness and Public-Private Partnerships: Towards a More Decentralised Policy [PDF]

In this contribution, we analyse the pattern of the so-called PIP (Partnerships and Public Initiatives) that have been approved between 2000 and mid-2003 in the POE1 framework.
Mário Rui Silva, Hermano Rodrigues
core   +2 more sources

Early prediction of vasopressor initiation in ICU sepsis patients using an interpretable EHR-based ML model

BMC Medical Informatics and Decision Making
Background Early identification of septic patients who will require vasopressor support could provide a critical window for hemodynamic optimisation, yet current bedside cues often appear only when shock is imminent.
Lucas Duval, Antoine Villié, Fei Zheng, Gabriel Terraz, Sophie Blein, Esther Duperchy, Martin Everett, Johan Frieling, Jean-François Llitjos, Maxime Bodinier   +9 more
doaj   +1 more source

Governing Partnerships

, 2010
Public private partnerships (PPPs) are instruments of the public interest, yet bodies that actively engage private actors. As a result, questions of governance are particularly important. Here, governance refers to the rules that prescribe who should make, execute and be accountable for the conduct of a PPP, and in what way that conduct should be ...
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source