Results 141 to 150 of about 56,444 (289)

The Microbiota Shapes Central Nervous System Myelination in Early Life

open access: yesAdvanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch   +13 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging

open access: yesAdvanced Science, EarlyView.
Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen   +3 more
wiley   +1 more source

Restricted mating windows and thrombospondin 2 gene deletion improve the precision of parturition timing in mice†. [PDF]

open access: yesBiol Reprod
Rogers JH   +11 more
europepmc   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

open access: yesAdvanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang   +12 more
wiley   +1 more source

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