Results 191 to 200 of about 102,508 (345)

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Rabbit Does as a Model for Studying Plasma Metabolomic Adaptations Across Reproductive Stages: Insights from Parturition to Weaning. [PDF]

Vet Sci
Mateo-López J, Huertas-Herrera A, Toro-Manríquez M, Páez-Rosas D, Hedemann MS, Llobat L, Marín-García PJ.   +6 more
europepmc   +1 more source

Progesterone, the maternal immune system and the onset of parturition in the mouse†

Biology of Reproduction, 2018
L. Edey, H. Georgiou, K. O’Dea, S. Mesiano, B. Herbert, K. Lei, R. Hua, D. Markovic, S. Waddington, D. MacIntyre, P. Bennett, M. Takata, Mark R. Johnson   +12 more
semanticscholar   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Monitoring reproduction in cryptic small mammals; using body temperature to identify parturition in an endangered rodent. [PDF]

Biol Open
Gérard T, Chignec H, Poteaux C, Long E, Habold C.   +4 more
europepmc   +1 more source

From Chatbots to Co‐Scientists: The Impact of Knowledge‐Generating AI (AI 4.0) on Healthcare and Research

Advanced Science, EarlyView.
This perspective contrasts the historical, linear progression of early AI with the dynamic, iterative nature of AI 4.0; and it describes the real‐world medical applications and the necessary evolution of laboratory infrastructure brought about by AI 4.0.
Weida Liu, Gary Peltz
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Prolificacy-survival trade-off in Morada Nova sheep under Brazilian semiarid conditions. [PDF]

Trop Anim Health Prod
Silveira RMF, Pereira AHR, Balistrieri M, Cortat PR, de Moraes Silva K, Carrara ER, Mcmanus C, Landim AV.   +7 more
europepmc   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Unusual Case of Simultaneous Vaginal and Rectal Prolapse in a Jennet: Clinical Presentation and Management. [PDF]

Case Rep Vet Med
Saraiva S, Silva F, García-Díez J.
europepmc   +1 more source