Results 241 to 250 of about 133,619 (388)

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

open access: yesJournal of Clinical Investigation, 2017
Patrice Nancy   +9 more
semanticscholar   +1 more source

Maladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CB1R Contributes to Diabetic Neuropathy

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
This study demonstrates the maladaptive peripheral ketogenesis in Schwann cells following diabetes mellitus, which serves as a contributor to diabetic peripheral neuropathy. The authors further propose cannabinoid type‐1 receptor in Schwann cells as a promising therapeutic target and JD5037 as a pharmacological intervention to reprogram Schwann cell ...
Weizhen Li   +8 more
wiley   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

open access: yesAdvanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang   +8 more
wiley   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

open access: yesAdvanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang   +4 more
wiley   +1 more source

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