Results 251 to 260 of about 133,619 (388)

Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
A new CdCS rat model is developed using CRISPR‐Cas9 technology. It shows impairments in cognitive and social behaviors, neuronal dendrite abnormalities in the hippocampus and mPFC, and inflammatory and immune processes in mPFC brain cells. Early AAV‐Ctnnd2 gene therapy enhances cognitive function in CdCS rats.
Jingjing Shen   +11 more
wiley   +1 more source

Cesarianas: percepção de risco e sua indicação pelo obstetra em uma maternidade pública no Município do Rio de Janeiro

open access: yesCadernos de Saúde Pública
A taxa de cesariana entre as maternidades públicas municipais da cidade do Rio de Janeiro no ano de 2000 foi de 30,1%. Com taxas tão elevadas, nossas hipóteses são que as indicações de cesarianas nestas unidades não estão restritas apenas às indicações ...
Marcos Augusto Bastos Dias   +1 more
doaj  

A retrospective study on dystocia in the cat, evaluation of 111 cases. [PDF]

open access: yesActa Vet Scand
Axnér E   +3 more
europepmc   +1 more source

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage

open access: yesAdvanced Science, EarlyView.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang   +10 more
wiley   +1 more source

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi   +13 more
wiley   +1 more source

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