Results 51 to 60 of about 12,590,474 (284)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Experimental Aerodynamics of a Small Fixed-Wing Unmanned Aerial Vehicle Coated with Bio-Inspired Microfibers Under Static and Dynamic Stall

Aerospace
A passive flow control technique in the form of microfiber coatings with a diverging pillar cross-section area was applied to the wing suction surface of a small tailless unmanned aerial vehicle (UAV). The coatings are inspired from ‘gecko feet’ surfaces,
Dioser Santos, Guilherme D. Fernandes, Ali Doosttalab, Victor Maldonado   +3 more
doaj   +1 more source

Improving the Lift Characteristics of Supersonic Double 257 Wedge Airfoil at Low Speed Using Passive-Active Flow Controlling Methods [PDF]

Engineering and Technology Journal, 2015
The supersonic double wedge airfoil performs quite excellent in the supersonic speed regime but would lead to poor performance at subsonic speed regime due to sharp edges stall.
Mohammed I.Abutabikh, AbdulKareem Al-Musawi, Mohammed K. Khashan   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Suppression of Fluid Forces Acting on Two Square Prisms in Tandem Arrangement by Passive Control. [PDF]

The aim of the present study is to suppress the fluid forces acting on two square prisms in tandem arrangement, which is found in many cases in structures on land and in the ocean, by exerting passive control on an approaching flow using a small flat ...
坂本, 弘志, Alam, Md.Mahbub, 高井, 和紀, Takai, kazunori, 森谷, 優   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Numerical Investigation of Passive Flow Control over an External Backward-Facing Step Using Rigid and Elastic Plates

Applied Sciences
This study investigates the passive control of backward-facing step flows using rigid and elastic cantilevered plates, with emphasis on flow reattachment, pressure recovery, and fluid–structure interaction effects.
Baris Gungordu, Matin Hasanli
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Numerical and Experimental Assessment of a Passive Flow-Control Strategy for Vertical-Axis Wind Turbine Blades

Technologies
Vertical-axis wind turbines are attractive for urban energy applications, but modest efficiency still constrains their wider use. This study evaluates a passive flow-control solution consisting of 45°-inclined cavities introduced on the suction side of a
Ioana-Octavia Bucur, Daniel-Eugeniu Crunțeanu, Mădălin-Constantin Dombrovschi   +2 more
doaj   +1 more source