Results 41 to 50 of about 165,037 (262)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Passive Control Measures of Wind Flow around Tall Buildings

Buildings
The growth and diversification of tall buildings demands higher performance standards that encompass serviceability and resilience. In this respect, the control of air flow around tall buildings poses challenges to minimising the energy that could induce
Mario A. Aguirre-López, Filiberto Hueyotl-Zahuantitla, Pedro Martínez-Vázquez   +2 more
doaj   +1 more source

Effects of Active and Passive Control Techniques on Mach 1.5 Cavity Flow Dynamics

International Journal of Aerospace Engineering, 2017
Supersonic flow over cavities has been of interest since 1960s because cavities represent the bomb bays of aircraft. The flow is transient, turbulent, and complicated. Pressure fluctuations inside the cavity can impede successful weapon release.
Selin Aradag, Kubra Asena Gelisli, Elcin Ceren Yaldir   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Experimental Aerodynamics of a Small Fixed-Wing Unmanned Aerial Vehicle Coated with Bio-Inspired Microfibers Under Static and Dynamic Stall

Aerospace
A passive flow control technique in the form of microfiber coatings with a diverging pillar cross-section area was applied to the wing suction surface of a small tailless unmanned aerial vehicle (UAV). The coatings are inspired from ‘gecko feet’ surfaces,
Dioser Santos, Guilherme D. Fernandes, Ali Doosttalab, Victor Maldonado   +3 more
doaj   +1 more source

Improving the Lift Characteristics of Supersonic Double 257 Wedge Airfoil at Low Speed Using Passive-Active Flow Controlling Methods [PDF]

Engineering and Technology Journal, 2015
The supersonic double wedge airfoil performs quite excellent in the supersonic speed regime but would lead to poor performance at subsonic speed regime due to sharp edges stall.
Mohammed I.Abutabikh, AbdulKareem Al-Musawi, Mohammed K. Khashan   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Passive control of circular cylinder wake in shallow flow

Measurement, 2013
Abstract The control of vortex shedding of a circular cylinder in shallow water using a splitter plate located in the downstream of the circular cylinder was studied by employing particle image velocimetry (PIV) technique. Experiments were carried out in a water channel having a test section of 8000 mm × 1000 mm × 750 mm dimensions at a Reynolds ...
Gozmen, Bengi, Akilli, Huseyin, Sahin, Besir   +2 more
openaire   +2 more sources