Results 31 to 40 of about 25,919 (256)

Numerical Simulation of Natural Circulation Characteristic of Fast Reactor Passive Decay Heat Removal System Based on “1-D System+3-D CFD” Coupled Method

Yuanzineng kexue jishu
The sodium-cooled fast reactor is one of the important reactor types of the fourth-generation advanced nuclear energy system. The safety of sodium-cooled fast reactors is improved by introducing a new passive decay heat removal system.
LU Daogang1, 2, SONG Haijie1, 2, GUO Jinsong1, 2, ZHAO Haiqi1, 2, ZHANG Yuhao1, 2, , , SUI Danting1, 2
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design and analysis of passive residual heat removal system for a new megawatt and compact nuclear power plant

He jishu
BackgroundA heat pipe reactor is ideal for underwater unmanned vehicles (UUV) because it is simple, is compact, and has high inherent safety.PurposeA passive residual heat removal system that uses natural circulation to cool the adiabatic section of heat
YUAN Leqi, WU Hexin, GOU Junli, SHAN Jianqiang   +3 more
doaj   +1 more source

Application of Chernoff bound to passive system reliability evaluation for probabilistic safety assessment of nuclear power plants

Nuclear Engineering and Technology, 2022
There is an increasing interest in passive safety systems to minimize the need for operator intervention or external power sources in nuclear power plants. Because a passive system has a weak driving force, there is greater uncertainty in the performance
Eunseo So, Man Cheol Kim
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Heat Transfer Analysis of Passive Residual Heat Removal Heat Exchanger under Tube outside Boiling Condition

Science and Technology of Nuclear Installations, 2017
The Passive Residual Heat Removal Heat Exchanger (PRHR HX) is an important part of the Passive Residual Heat Removal System (PRHRS). The C-shaped bundle is being used in the PRHR HX.
Yanbin Liu, Xuesheng Wang, Qiming Men, Xiangyu Meng, Qing Zhang   +4 more
doaj   +1 more source

Universal system of passive heat removal from the core of a research reactor [PDF]

Nuclear Technology and Radiation Protection, 2019
This paper presents the results of an analysis of a universal cooling system for the core of re- search reactors built on the passive principle of natural convection.
Uzikov Vitaly, Uzikova Irina
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Verification of Advanced Secondary Passive Residual Heat Removal System Based on Full-Scope Simulator

南方能源建设, 2022
[Introduction] As an important design improvement to cope with the station black out (SBO) accident, the advanced secondary passive residual heat removal (ASP) system is based on the closed natural circulation of secondary side of the steam generator (SG)
Jinchao LIU, Tongsheng WANG, Yaozu LIN, Heng ZHANG, Rui SHA   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source