Results 31 to 40 of about 19,571,298 (238)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Universal system of passive heat removal from the core of a research reactor [PDF]
Nuclear Technology and Radiation Protection, 2019 This paper presents the results of an analysis of a universal cooling system for the core of re- search reactors built on the passive principle of natural convection.
Uzikov Vitaly, Uzikova Irina
doaj +1 more source
Nuclear Engineering and Technology, 2022 There is an increasing interest in passive safety systems to minimize the need for operator intervention or external power sources in nuclear power plants. Because a passive system has a weak driving force, there is greater uncertainty in the performance
Eunseo So, Man Cheol Kim
doaj +1 more source
南方能源建设, 2022 [Introduction] As an important design improvement to cope with the station black out (SBO) accident, the advanced secondary passive residual heat removal (ASP) system is based on the closed natural circulation of secondary side of the steam generator (SG)
Jinchao LIU +4 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Geothermal ground heat exchangers in Malta : thermal performance assessment of infill grouts [PDF]
, 2013 The aim of this paper was to assess the thermal conductivity of proprietary grout mixes versus local ones in Malta. Ground source heat pump (GSHP) systems consume 75% less electricity than conventional environmental control systems and have lower ...
Runco, Lara +3 more
core
Benchmark exercise on ELSMOR passive heat removal system
The EU-funded ELSMOR (Towards European Licencing of Small Modular Reactors) project seeks to design methods and tools for stakeholders to assess and verify Light Water SMRs’ safety when installed across Europe.
Nikitin, K. +9 more
core +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Performance analysis of the SPRHRS for the 1000 MWe class PWR in coping with station black out
International Journal of Advanced Nuclear Reactor Design and Technology, 2020 In order to improve the safety and reliability of the Chinese nuclear power plants (NPP), an innovative passive nuclear safety design, the secondary passive residual heat removal system (SPRHRS) is proposed for the light water reactors in China. Previous
Qiqi Yan +3 more
doaj +1 more source
Nuclear Engineering and Technology, 2021 Passive containment cooling systems (PCCSs) have been actively studied to improve the inherent safety of nuclear power plants. Hered, we present two concepts, open-loop PCCS (OL-PCCS) and closed-loop PCCS (CL-PCCS), applicable to the PWR with a concrete ...
Jungjin Bang +2 more
doaj +1 more source