Results 31 to 40 of about 43,258 (202)

The burden of COVID-19 in a heterogeneous population of immunocompromised patients – realities of the postpandemic

Терапевтический архив, 2023
On July 3, 2023, an interdisciplinary Council of Experts The burden of COVID-19 in a heterogeneous population of immunocompromised patients post-pandemic realities was held in Moscow with leading experts in pulmonology, rheumatology, hematology ...
Sergey N. Avdeev, Vladimir P. Chulanov, Ekaterina I. Alexeeva, Olga A. Aleshina, Aleksey V. Bereznikov, Oleg N. Kotenko, Aleksander M. Lila, Zinaida Yu. Mutovina, Elena N. Parovichnikova, Daria S. Fomina, Nadiya F. Frolova, Alexey O. Shevchenko   +11 more
doaj   +1 more source

Emerging antibody-based products for infectious diseases: Planning for metric ton manufacturing

Human Vaccines & Immunotherapeutics, 2022
This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand.
Kevin J Whaley, Larry Zeitlin
doaj   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Immunization With Recombinant Haemonchus contortus Y75B8A.8 Partially Protects Local Crossbred Female Goats From Haemonchus contortus Infection

Frontiers in Veterinary Science, 2022
Haemonchus contortus Y75B8A.8 (Hc8) derived from H. contortus excretory–secretory (ES) products was identified as a functional inhibitor of goat interleukin 2 (IL-2). It may act as a vaccine candidate for the development of therapeutic strategies against
Xiaowei Tian, Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li, Xiangrui Li   +12 more
doaj   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Care and COVID 19: Lessons for liberals and neoliberals

Child &Family Social Work, EarlyView., 2023
Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley   +1 more source

Triple‐Helix Biomolecules Construct Self‐Adaptive Multi‐Phase Interfaces for Dendrites Immunized Zinc Metal Anodes

Advanced Science, EarlyView.
A bio‐derived triple‐helix framework enables adaptive interphase engineering for aqueous Zn metal batteries. Directional Zn2+ migration channels and dynamic transformation into β‐sheet domains construct an optimized solid electrolyte interphase with flexible–rigid synergy, delivering dendrite‐free Zn deposition and exceptional long‐term battery cycling
Tianyi Wang, Jiahui Lu, Wei Gu, Jianfei Shi, Yuting Qin, Jian Yang, Di He, Zixia Lin, Jiabao Li, Bing Sun, Guoxiu Wang, Chengyin Wang   +11 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Passive Immunization of Farmed Fish [PDF]

The Journal of Immunology, 2017
Abstract The fast growth and potential of global aquaculture has necessitated the adoption of sustainable and welfare-oriented therapeutics and prophylactic strategies. Knowledge gathered from studies about maternal passive immunity in fish and fish-to-fish passive immunization experiments supports the concept of using therapeutic Abs ...
Binoy, Rajan, Guro, Løkka, Erling Olaf, Koppang, Lars, Austbø   +3 more
openaire   +2 more sources