Results 21 to 30 of about 7,048,337 (171)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Reconfigurable nodes for passive optical networks (PON) [PDF]

, 2009
Mestrado em Engenharia Electrónica e TelecomunicaçõesRecentemente , as redes ópticas de nova geração têm sido motivo de acesa discussão nos meios científicos.
Ferreira, Marco Paulo Flores
core  

Photonic Integrated Circuits for NGPON2 ONU Transceivers (Invited)

Applied Sciences, 2020
The development of photonic integrated circuits (PIC) for access network applications, such as passive optical networks (PON), constitutes a very attractive ecosystem due to PON’s potential mass market. The implementation of PIC solutions in this context
Cátia Pinho, Francisco Rodrigues, Ana Maia Tavares, Carla Rodrigues, Cláudio Emanuel Rodrigues, António Teixeira   +5 more
doaj   +1 more source

Key Technologies for a Beyond-100G Next-Generation Passive Optical Network

Photonics, 2023
The explosive development of emerging telecommunication services has stimulated a huge growth in bandwidth demand as people seek universal access to telecommunication networks.
Nan Feng, Mingyi Ma, Yinsong Zhang, Xiaochuan Tan, Zhe Li, Shaobo Li   +5 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Reconfigurable remote nodes for hybrid passive optical networks [PDF]

, 2008
Mestrado em Engenharia Electrónica e TelecomunicaçõesO presente documento tem por objectivo demonstrar, analisar e optimizar nós remotos passivos para redes ópticas passivas baseadas numa topologia de anel de dupla fibra com multiplexagem no comprimento ...
Baptista, Albano Manuel Cardoso
core  

Fiber- and FSO-Protected Connections for Long-Reach TWDM Access Architecture With Fault Protection

IEEE Access, 2020
In this paper, we propose a long-reach star-ring-based timeand wavelength-divisionmultiplexing passive optical network (TWDM-PON) by using fiberand free space optical (FSO)-protected architecture against fiber breakpoint.
Chien-Hung Yeh, Wei-Hung Hsu, Bo-Yin Wang, Wei-Yao You, Jhao-Ren Chen, Chi-Wai Chow, Shien-Kuei Liaw   +6 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Adaptive Scheduling Algorithm for the Coexistence of ONUs with Different Tuning Time in Virtual Passive Optical Network

IEEE Photonics Journal, 2019
Optical network unit (ONU)'s wavelength tuning time is a key factor that cannot be ignored in ONU scheduling algorithm for multi-wavelengths passive optical network (PON).
Xingdi Wang, Chaoqin Gan, Liya Tong
doaj   +1 more source

Changes in land‐snail communities and steppe environments in the lower Rhône valley during the Lateglacial–Holocene transition

Boreas, EarlyView.
Land snail successions in the lower Rhône valley allow us to reconstruct the postglacial recolonization. From the Lateglacial period onwards, Mediterranean steppe communities appeared. The arrival of forest taxa was significantly delayed by aridity. The question of glacial refugia, both local and distant, primarily concerned Mediterranean species of ...
Frédéric Magnin
wiley   +1 more source