Results 151 to 160 of about 6,051,489 (245)

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

open access: yesAdvanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang   +7 more
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

open access: yesAdvanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li   +11 more
wiley   +1 more source

Flame Suppression in Lithium‐Ion Batteries During Thermal Runaway Through Solvent Design Considering the Volatility–Flammability Relationship

open access: yesAdvanced Science, EarlyView.
An asymmetric sulfonate solvent forms thermally stable interphases and demonstrates non‐flammability, suppressing heat accumulation for safer, high‐performance lithium‐ion batteries. ABSTRACT An asymmetric sulfonate‐based linear solvent, 2,2,2‐trifluoromethyl mesylate (FMS), is designed and used as the primary solvent in liquid electrolytes to enhance ...
Chi‐Yeong Hong   +12 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

open access: yesAdvanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang   +18 more
wiley   +1 more source

Vaccine-Associated Anterior Uveitis. [PDF]

open access: yesVaccines (Basel)
Ghalibafan S   +5 more
europepmc   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

open access: yesAdvanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens   +11 more
wiley   +1 more source

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