Results 31 to 40 of about 115,159 (252)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The passive safety system of a high-speed multiple-unit train [PDF]

MATEC Web of Conferences
The designing of modern high-speed multiple-unit trains in Ukraine should be carried out accounting for passive safety systems (PSSs) which include energy absorption devices (EADs).
Sobolevska Maryna, Horobets Dmytro
doaj   +1 more source

Research of active safety systems for motor vehicles [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2020
Problem. The causes of accidents can be different – they include a human factor and the state of the road, and meteorological conditions, it is necessary to anticipate the full range of potentially dangerous situations, in which, theoretically, can a car
Korostelev Nikolay, Hnatov Andrii
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluation of the Effectiveness of Active and Passive Safety Measures in Preventing Ship–Bridge Collision

Sensors, 2022
The risk of ship–bridge collisions should be evaluated using advanced models to consider different anti-collision and bridge-protection measures. This study aimed to propose a method to evaluate the effectiveness of active and passive safety measures in ...
Wenqing Ma, Yini Zhu, Manel Grifoll, Guiyun Liu, Pengjun Zheng   +4 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

IMPROVEMENT OF ROAD SAFETY USING PASSIVE AND ACTIVE INTELLIGENT VEHICLE SAFETY SYSTEMS

TRANSPORT, 2007
Following the measures foreseen in the Transport White Paper 2001, situation of road safety has improved. Road fatalities have declined by more than 17 % since 2001 in the EU. However, with around 41 600 deaths and more than 1.7 million injured in 2005, road remains the least safe mode of transport and objectives to halve the number of fatalities on ...
Jarašūnienė, Aldona, Jakubauskas, Gražvydas   +1 more
openaire   +5 more sources

Passive electrochemical hydrogen recombiner for hydrogen safety systems: prospects

Nuclear Science and Techniques, 2023
AbstractThis paper presents the concept of a passive electrochemical hydrogen recombiner (PEHR). The reaction energy of the recombination of hydrogen and oxygen is used as a source of electrical energy according to the operating principle for hydrogen fuel cells to establish forced circulation of the hydrogen mixture as an alternative to natural ...
Avdeenkov, A. V., Bessarabov, D. G., Zaryugin, D. G.   +2 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Safety Design and Evaluation in a Large-Scale Japan Sodium-Cooled Fast Reactor

Science and Technology of Nuclear Installations, 2012
As a next-generation plant, a large-scale Japan sodium-cooled fast reactor (JSFR) adopts a number of innovative technologies in order to achieve economic competitiveness, enhanced reliability, and safety. This paper describes safety requirements for JSFR
H. Yamano, S. Kubo, Y. Shimakawa, K. Fujita, T. Suzuki, K. Kurisaka   +5 more
doaj   +1 more source