Results 91 to 100 of about 29,184,853 (263)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Passivity-Based Control for Output Voltage Regulation in a Fuel Cell/Boost Converter System. [PDF]

Micromachines (Basel), 2023
Beltrán CA, Diaz-Saldierna LH, Langarica-Cordoba D, Martinez-Rodriguez PR.   +3 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Sensitivity Analysis of Krasovskii Passivity-Based Controllers

, 2022
In the domain of passivity theory, there were major contributions in the last decade, the most recent notion of passivity being the so-called Krasovskii passivity.
Vlad Mihaly, Mircea Şuşcă, Dora Morar, Petru Dobra   +3 more
core   +1 more source

Decentralized Control of DC Microgrids Using Interconnection and Damping Assignment Passivity-Based Control Technique: Experimental Verification

IEEE Access
A decentralized control approach is introduced in this paper that utilizes passivity-based control for two DC-distributed energy sources supplying the power of a load. Considering the concept of passivity, if each distributed generator exhibits passivity,
Mohammad Afkar, Cong Yuan, Roghayeh Gavagsaz-Ghoachani, Wiset Saksiri, Matheepot Phattanasak, Jean-Philippe Martin, Serge Pierfederici   +6 more
doaj   +1 more source

Optimally Biomimetic Passivity-Based Control of a Lower-Limb Exoskeleton Over the Primary Activities of Daily Life. [PDF]

IEEE Open J Control Syst, 2022
Lin J, Divekar NV, Thomas GC, Gregg RD.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Passivity-Based Integral Sliding Mode Control for Robust Trajectory Tracking in 2-DOF Helicopter Systems

Algerian Journal of Signals and Systems
This study introduces a robust trajectory-tracking control strategy in a two-degrees-of-freedom (2-DOF) helicopter system, combining passivity theory and integral sliding mode control (ISMC) strengths.
Ratiba Fellag, Mahmoud Belhocine, Meziane Hamel   +2 more
doaj   +1 more source

A Feedback Passivation Design for DC Microgrid and Its DC/DC Converters

Energies, 2016
There are difficulties in analyzing the stability of microgrids since they are located on various network structures. However, considering that the network often consists of passive elements, the passivity theory is applied in this paper to solve the ...
Feifan Ji, Ji Xiang, Wuhua Li, Quanming Yue   +3 more
doaj   +1 more source