Results 41 to 50 of about 597,160 (277)

Darwin's manufactory hypothesis is confirmed and predicts the extinction risk of extant birds. [PDF]

PLoS ONE, 2009
In the Origin of Species Darwin hypothesized that the "manufactory" of species operates at different rates in different lineages and that the richness of taxonomic units is autocorrelated across levels of the taxonomic hierarchy.
David G Haskell, Anupam Adhikari
doaj   +1 more source

ON THE PAST AND FUTURE OF NULL HYPOTHESIS SIGNIFICANCE TESTING1 [PDF]

ETS Research Report Series, 2001
ABSTRACTCriticisms of null hypothesis significance testing (NHST) have appeared recently in wildlife research journals (Anderson, Burnham, & Thompson, 2000; Anderson, Link, Johnson, & Burnham, 2001; Cherry, 1998; Guthery, Lusk, & Peterson, 2001; Johnson, 1999).
Daniel H. Robinson, Howard Wainer
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Testing two competing hypotheses for Eurasian jays’ caching for the future

Scientific Reports, 2021
Previous research reported that corvids preferentially cache food in a location where no food will be available or cache more of a specific food in a location where this food will not be available.
Piero Amodio, Johanni Brea, Benjamin G. Farrar, Ljerka Ostojić, Nicola S. Clayton   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Vehicle Detection Based on Probability Hypothesis Density Filter

Sensors, 2016
In the past decade, the developments of vehicle detection have been significantly improved. By utilizing cameras, vehicles can be detected in the Regions of Interest (ROI) in complex environments.
Feihu Zhang, Alois Knoll
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Time arrow without past hypothesis: a toy model explanation

New Journal of Physics
The laws of Physics are time-reversible, making no qualitative distinction between the past and the future—yet we can only go towards the future. This apparent contradiction is known as the ‘arrow of time problem’.
Pablo Arrighi, Gilles Dowek, Amélia Durbec   +2 more
doaj   +1 more source