Results 61 to 70 of about 793,583 (297)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Boletín de Literatura Oral, 2018 Resumen. En el presente artículo se publican cuatro versiones bereberes del cuento El joven pastor en poder de los asaltantes que nos obligarán a replantearnos las teorías acerca del origen y de la distribución del relato.
Óscar Abenójar
doaj +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The Pastor as Bearer of Hope [PDF]
, 1994 Lutheran Life Lecture, Waterloo Lutheran Seminary, November 4 ...
Capps, Donald
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
#ChurchToo, Kekerasan Seksual di Gereja dan Penguatan Komunitas
Dunamis: Jurnal Teologi dan Pendidikan Kristiani. The hashtag movement like #ChurchToo has become one of the ways for sexual violence survivors to express their experiences of sexual violence they have experienced in the church. #ChurchToo has an influence not only on the survivors' attitudes but also
Ruth Rosani Saiya +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Economía, Sociedad y Territorio, 2006 De la revisión de las normas constitucionales y legales en los códigos electorales del país se concluye que existen diferentes niveles de restricciones para partidos políticos y para ministros de culto, principalmente por razones históricas.
ALEJANDRO DÍAZ DOMÍNGUEZ
doaj +1 more source