Results 101 to 110 of about 7,799,898 (315)

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Linking remote-sensing estimates of land cover and census statistics on land use to produce maps of land use of the conterminous United States [PDF]

, 2001
Human use of the land has a large effect on the structure of terrestrial ecosystems and the dynamics of biogeochemical cycles. For this reason, terrestrial ecosystem and biogeochemistry models require moderate resolution (e.g., ≤0.5°) information on land
Belward, Berrien Moore, Brower, Frolking, George C. Hurtt, Houghton, Hurtt, Kates, Loveland, Lynn Rosentrater, Metropolis, Press, Ramankutty, Scepan, Schimel, Skole, Smil, Steve Frolking, Vitousek, Vitousek, Vorosmarty, Yang   +21 more
core   +2 more sources

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

Advanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears, Kerrianne Harrington, Jonathan C. Knight, William J. Wadsworth, James M. Stone, Tim A. Birks   +5 more
wiley   +1 more source

Long-term impacts of conservation pasture management in manuresheds on system-level microbiome and antibiotic resistance genes. [PDF]

Front Microbiol, 2023
Seyoum MM, Ashworth AJ, Feye KM, Ricke SC, Owens PR, Moore PA, Savin M.   +6 more
europepmc   +1 more source

Small U.S. Dairy Farms: Can They Compete? [PDF]

The U.S. dairy industry is undergoing rapid structural change, evolving from a structure including many small farmers in the Upper Midwest and Northeast to one that includes very large farms in new production regions. Small farms are struggling to retain
Gillespie, Jeffrey M., Hallahan, Charles B., Nehring, Richard F., Sandretto, Carmen L.   +3 more
core   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Long-term survival of Ascaris suum and Trichuris suis eggs in relation to pasture management [PDF]

, 2011
Background: Organic pig production systems are commonly characterized by high helminth prevalences. This problem is partly associated with access to outdoor facilities such as pastures and more knowledge is needed on long-term pasture infectivity ...
Mejer, Helena, Roepstorff, Allan
core  

Obesity prevalence and associated risk factors in outdoor living domestic horses and ponies [PDF]

, 2014
Reasons for performing study. The prevalence of obesity in companion animals, including horses and ponies has risen drastically in recent years and risk factors have been little investigated.
Giles, Sarah L, Harris, Patricia A., Nicol, Christine J, Rands, Sean A   +3 more
core   +3 more sources

Critical Limitations in Cryogenic Laser Cooling of Solids: Symmetry‐Related Fluorescence Trapping and Condensation‐Induced Parasitic Heating

Advanced Science, EarlyView.
This study uncovers two overlooked bottlenecks in cryogenic laser cooling of solids: symmetry‐driven fluorescence trapping and water vapor condensation. We demonstrate that breaking sample symmetry enhances fluorescence escape, while condensation dominates parasitic heating below 135 K.
Biao Zhong, Jiayi Zhang, Haodong Yang, Lianzhong Deng, Mauro Tonelli, Ercang Luo   +5 more
wiley   +1 more source

Using On-Farm Monitoring of Ergovaline and Tall Fescue Composition for Horse Pasture Management. [PDF]

Toxins (Basel), 2021
Lea KM, Smith SR.
europepmc   +1 more source