Results 21 to 30 of about 27,521 (266)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effects of liming and nitrogen application on the trace element concentrations of pastures in low mountain range

Plant, Soil and Environment, 2007
In less intensively managed grassland, the micronutrient concentrations in herbage are apparently more likely to be in levels between barely sufficient and deficient than to be excessively high.
H. Laser
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Effect of Ecotype and Cutting Frequency on Forage Yields of Moringa oleifera Lam in the Cauto Valley

Revista de Producción Animal, 2018
The study took place at the Experimental Station of Pastures and Forages to evaluate the effect of the cut frequency (45 and 60 days) on forage yields of Moringa oleifera ecotypes Nicaragua and Criolla, with irrigation and organic fertilization, on ...
José Ledea Rodríguez , Giselle Rosell Alonso , Diocles Benítez Jiménez , Ramón Arias Pérez , Jorge Ray Ramírez , Yordanis Nuviola Pérez   +5 more
doaj  

Paspalum lepton - a valuable adjunct to the suite of grasses used in grazing systems in the subtropics or a potential weed

Tropical Grasslands-Forrajes Tropicales
Native and exotic C4 grasses currently used in grazing systems in the subtropics have specific limitations with management, decline in feed quality as they mature and variable adaptation to soils and climates, providing opportunities to identify ...
Bruce G. Cook, David L. Lloyd, Walter J. Scattini, Alan D. Robertson   +3 more
doaj   +1 more source

Forests, Coca, and Conflict: Grass Frontier Dynamics and Deforestation in the Amazon-Andes

Journal of Illicit Economies and Development, 2021
Population growth with weak economic development can promote tropical deforestation, but government infrastructure investment can also open new frontiers and thus increase deforestation. In the Andean region of South America, population growth has been a
Liliana M. Davalos, Eleonora Davalos, Jennifer Holmes, Clara Tucker, Dolors Armenteras   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Establishing New Cenchrus purpureus Varieties in a Fragile Ecosystem in the Cauto River Valley, Granma, Cuba

Revista de Producción Animal, 2018
Some indicators that determine the capacity to establish new varieties of Cenchrus purpureus (CT-801, CT-802, CT-803, CT-804, and CT-805), tolerant to droughts and salinity, in a fragile ecosystem in the province of Granma, Cuba, were evaluated.
Jorge Valentín Ray Ramírez , José Leonardo Ledea Rodríguez , Ramón Crucito Arias Pérez   +2 more
doaj  

The importance of grasslands for animal production and other functions: a review on management and methodological progress in the tropics

Animal, 2012
The global importance of grasslands is indicated by their extent; they comprise some 26% of total land area and 80% of agriculturally productive land.
M. Boval, R.M. Dixon
doaj   +1 more source

The Pasture-Type Approach for Mountain Pasture Description and Management

Italian Journal of Agronomy, 2012
The study of pastoral resources can take different approaches with the main goal of characterizing pasture vegetation and its potential carrying capacity. In recent times, the pasture-type approach has been developed in several Alpine areas – on a regional and on a district scale – starting from sward surveys carried out taking the approach formerly ...
ARGENTI, GIOVANNI, G. Lombardi
openaire   +4 more sources