Results 31 to 40 of about 67,350 (297)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Growth and biomass allocation of the C4 grasses Brachiaria brizantha and B. humidicola under shade Crescimento e alocação de biomassa nas gramíneas C4 Brachiaria brizantha e B. humidicola sob sombreamento

Pesquisa Agropecuária Brasileira, 2000
The growth and biomass allocation responses of the tropical forage grasses Brachiaria brizantha cv. Marandu and B. humidicola were compared for plants grown outdoors, in pots, in full sunlight and those shaded to 30% of full sunlight over a 30day period.
MOACYR BERNARDINO DIAS-FILHO
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Sources of nitrous oxide from intensively managed pasture soils: the hole in the pipe

Environmental Research Letters, 2021
Rainfall and irrigation trigger large pulses of the powerful greenhouse gas N _2 O from intensively managed pastures, produced via multiple, simultaneously occurring pathways.
Johannes Friedl, Clemens Scheer, Daniele De Rosa, Christoph Müller, Peter R Grace, David W Rowlings   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cattle grazing on semi-natural pastures [PDF]

, 2010
The knowledge of the grazing behaviour of cattle on Swedish semi-natural pastures and how this relates to the nutritional quality and quantity of the vegetation is low. In a situation where farming is being intensified both nationally and globally, it is
Pelve, Maja
core  

Effects of liming and nitrogen application on the trace element concentrations of pastures in low mountain range

Plant, Soil and Environment, 2007
In less intensively managed grassland, the micronutrient concentrations in herbage are apparently more likely to be in levels between barely sufficient and deficient than to be excessively high.
H. Laser
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effect of Ecotype and Cutting Frequency on Forage Yields of Moringa oleifera Lam in the Cauto Valley

Revista de Producción Animal, 2018
The study took place at the Experimental Station of Pastures and Forages to evaluate the effect of the cut frequency (45 and 60 days) on forage yields of Moringa oleifera ecotypes Nicaragua and Criolla, with irrigation and organic fertilization, on ...
José Ledea Rodríguez , Giselle Rosell Alonso , Diocles Benítez Jiménez , Ramón Arias Pérez , Jorge Ray Ramírez , Yordanis Nuviola Pérez   +5 more
doaj  

Paspalum lepton - a valuable adjunct to the suite of grasses used in grazing systems in the subtropics or a potential weed

Tropical Grasslands-Forrajes Tropicales
Native and exotic C4 grasses currently used in grazing systems in the subtropics have specific limitations with management, decline in feed quality as they mature and variable adaptation to soils and climates, providing opportunities to identify ...
Bruce G. Cook, David L. Lloyd, Walter J. Scattini, Alan D. Robertson   +3 more
doaj   +1 more source