Results 111 to 120 of about 128,853 (246)

High throughput microbalance and methods of using same [PDF]

open access: yes, 2007
The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program.
Carlson, Eric   +4 more
core  

A variational method for quantitative photoacoustic tomography with piecewise constant coefficients

open access: yes, 2015
In this article, we consider the inverse problem of determining spatially heterogeneous absorption and diffusion coefficients from a single measurement of the absorbed energy (in the steady-state diffusion approximation of light transfer).
Beretta, Elena   +3 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

open access: yesAdvanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj   +21 more
wiley   +1 more source

A holistic and participatory information system for rural water and sanitation sector in Latin America and the Caribbean [PDF]

open access: yes, 2016
The provision of water supply, sanitation and hygiene services has emerged as a top priority in the development agenda in Latin American and the Caribbean.
Flores Baquero, Óscar   +3 more
core  

Analytical Cost Metrics : Days of Future Past

open access: yes, 2018
As we move towards the exascale era, the new architectures must be capable of running the massive computational problems efficiently. Scientists and researchers are continuously investing in tuning the performance of extreme-scale computational problems.
Djidjev, Hristo   +2 more
core   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

open access: yesAdvanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria   +7 more
wiley   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

open access: yesAdvanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao   +11 more
wiley   +1 more source

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

open access: yesAdvanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden   +11 more
wiley   +1 more source

Analysis and critical review of ICH Q8, Q9 and Q10 from a generic pharmaceutical industry view point [PDF]

open access: yesMakedonsko Farmacevtski Bilten, 2012
Generic industry aims to produce safe, efficient, built-in quality medicines that will satisfy patients’ requirements and will be competitive on the market.
Ljuba Karanakov   +3 more
doaj  

Convergence in a Stochastic Dynamic Heckscher-Ohlin Model [PDF]

open access: yes
The authors characterize the equilibrium for a small economy in a dynamic Heckscher-Ohlin model with uncertainty. They show that, when trade is balanced period-by-period, the per capita output and consumption of a small open economy converge to an ...
Malik Shukayev, Partha Chatterjee
core  

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