Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)
CHIMIA, 2009 Process Analytical Technology (PAT) launched by the U.S. Food and Drug Administration (FDA) aims to ensure the quality of pharmaceutical products. One important tool to obtain a deeper process understanding is the use of modern real-time process
Tobias Broger +3 more
doaj +3 more sources
Symposium on Process Analytical Technology (PAT) at ILMAC Lausanne 2018
CHIMIA, 2018 David Spichiger, Tobias Merz
doaj +5 more sources
Pharmaceutics, 2023 The measurement of product temperature is one of the methods that can be adopted, especially in the pharmaceutical industry, to monitor the freeze-drying process and to obtain the values of the process parameters required by mathematical models useful ...
Alberto Vallan +3 more
doaj +1 more source
Measurement of Paracetamol Concentration Using an Erbium-Doped Fiber Ring Cavity
Photonics, 2023 Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol,
Liliana Soares +5 more
doaj +1 more source
Development and Validation of an In‐Line API Quantification Method Using AQbD Principles Based on UV‐Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process [PDF]
, 2020 open access journalA key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls.
Almeida, Juan +5 more
core +2 more sources
BioTech 2017 Conference Report, Wädenswil, 7./8.9.2017
CHIMIA, 2017 Almost 200 scientists and professionals from academia and industry attended the BioTech 2017 conference at the Zurich University of Applied Sciences (ZHAW) in Wädenswil on 7./8. September 2017.
Caspar Demuth
doaj +1 more source
Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors
Sensors, 2022 Raman spectroscopy is an analytical technology for the simultaneous measurement of important process parameters, such as concentrations of nutrients, metabolites, and product titer in mammalian cell culture.
Alexander Graf +6 more
doaj +1 more source
Real-time assessment of critical quality attributes of a continuous granulation process [PDF]
, 2013 There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián +6 more
core +1 more source
Demonstrating Functional Equivalence of Pilot and Production Scale Freeze-Drying of BCG. [PDF]
PLoS ONE, 2016 Process analytical technology (PAT)-tools were used to monitor freeze-drying of Bacille Calmette-Guérin (BCG) at pilot and production scale. Among the evaluated PAT-tools, there is the novel use of the vacuum valve open/close frequency for determining ...
R Ten Have +4 more
doaj +1 more source
Fluorescence-based analyser as a rapid tool for determining soluble protein content in dairy ingredients and infant milk formula [PDF]
, 2018 peer-reviewedAbstract: Milk protein, in particular native whey protein, is of interest to dairy manufacturers as a measure of functional and nutritional quality.
Esquerre, Carlos +4 more
core +1 more source