Results 11 to 20 of about 4,485 (257)

Fast and Non-Invasive Evaluation of Yeast Viability in Fermentation Processes Using Raman Spectroscopy and Machine Learning

Beverages, 2023
Fermentation processes used for producing alcoholic beverages such as beer, wine, and cider have a long history, having been developed early on across different civilizations. In most instances, yeast strains are used for fermentation processes, e.g., at
Raoul Heese, Jens Wetschky, Carina Rohmer, Susanne M. Bailer, Michael Bortz   +4 more
doaj   +1 more source

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Pharmaceutics, 2021
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry.
Eun Ji Kim, Ji Hyeon Kim, Min-Soo Kim, Seong Hoon Jeong, Du Hyung Choi   +4 more
doaj   +1 more source

The Rocky Road to a Digital Lab

CHIMIA, 2023
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister, Jason D. Williams, C. Oliver Kappe   +2 more
doaj   +1 more source

In Situ Quantification of Polyhydroxybutyrate in Photobioreactor Cultivations of Synechocystis sp. Using an Ultrasound-Enhanced ATR-FTIR Spectroscopy Probe

Bioengineering, 2021
Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ ...
Philipp Doppler, Christoph Gasser, Ricarda Kriechbaum, Ardita Ferizi, Oliver Spadiut   +4 more
doaj   +1 more source

Measurement of Paracetamol Concentration Using an Erbium-Doped Fiber Ring Cavity

Photonics, 2023
Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol,
Liliana Soares, Rosa Ana Pérez-Herrera, Susana Novais, António Ferreira, Susana Silva, Orlando Frazão   +5 more
doaj   +1 more source

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Sensors, 2022
Raman spectroscopy is an analytical technology for the simultaneous measurement of important process parameters, such as concentrations of nutrients, metabolites, and product titer in mammalian cell culture.
Alexander Graf, Angus Woodhams, Michael Nelson, Douglas D. Richardson, Steven M. Short, Mark Brower, Marek Hoehse   +6 more
doaj   +1 more source

BioTech 2017 Conference Report, Wädenswil, 7./8.9.2017

CHIMIA, 2017
Almost 200 scientists and professionals from academia and industry attended the BioTech 2017 conference at the Zurich University of Applied Sciences (ZHAW) in Wädenswil on 7./8. September 2017.
Caspar Demuth
doaj   +1 more source

Demonstrating Functional Equivalence of Pilot and Production Scale Freeze-Drying of BCG. [PDF]

PLoS ONE, 2016
Process analytical technology (PAT)-tools were used to monitor freeze-drying of Bacille Calmette-Guérin (BCG) at pilot and production scale. Among the evaluated PAT-tools, there is the novel use of the vacuum valve open/close frequency for determining ...
R Ten Have, K Reubsaet, P van Herpen, G Kersten, J-P Amorij   +4 more
doaj   +1 more source

Advances in Twin-Screw Granulation Processing

Pharmaceutics, 2021
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi, Vivek Trivedi, Steven A. Ross, Dennis Douroumis   +3 more
doaj   +1 more source

Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model for Different Cores

Pharmaceutics, 2020
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications.
Juliana Radtke, Hubertus Rehbaum, Peter Kleinebudde   +2 more
doaj   +1 more source