Results 41 to 50 of about 128,853 (246)

Current Industry Perspective on Process Analytical Technique Tools and their Recent Development in Pharmaceutical Oral Solid Dosage Formulations

Journal of Pharmacy
Current review offers extensive understanding and implementation of process analytical technology (PAT) tools in manufacturing of pharmaceutical oral solid dosage (OSD) forms to streamline product’s time to reach to market and increase profitability ...
Chinna Reddy Palem, Vamshi Krishna Lekkala   +1 more
doaj   +1 more source

Cylindrical IR-ATR Sensors for Process Analytics

Sensors, 2020
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitive ...
Armin Lambrecht, Carsten Bolwien, Jochen Erb, Hendrik Fuhr, Gerd Sulz   +4 more
doaj   +1 more source

Identifying pharmaceutical manufacturing equipment's surface roughness and mitigating robustness concerns when using specular reflectance Fourier-transform infrared (FTIR) spectroscopy for rapid cleaning verification

Talanta Open, 2022
Preventing cross-contamination during manufacturing is a regulatory requirement in the pharmaceutical manufacturing industry. One element of measures to prevent cross-contamination is the validation of cleaning processes for manufacturing equipment by ...
Apu Sarwar, Conor McSweeney, Joep Timmermans, Eric Moore   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study on the Growth and Regulation of Large-Particle Sr(OH)₂·8H₂O Crystals with Process Analytical Technology

Crystals, 2023
Sr(OH)2 is an indispensable strontium compound extensively harnessed in sugar refining, strontium lubricating wax formulation, and polymer plastic stabilization. Sr(OH)2·8H2O is the prevalent hydrate form of Sr(OH)2.
Binbin Shi, Yongjuan Zhang, Shudong Liang, Yanan Wang, Yan Jing, Xingwu Zou, Xuezhong Wang   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The application of mathematical and statistical methods in industry

Revista Técnica de la Facultad de Ingeniería, 2012
Chemometrics has been defined as “The discipline that uses mathematical and statistical methods for selection or design of optimal experimental conditions, and to provide relevant information from chemical data”.
Carlos Alciaturi, Marcos Escobar, Iván Esteves, Zoilabet Duque   +3 more
doaj  

The application of NIR spectroscopy with chemometric analysis for monitoring the powder blending process [PDF]

Journal of the Serbian Chemical Society, 2014
This paper reports the use of Near Infrared (NIR) spectroscopy as a Process Analytical Technology (PAT) tool for monitoring the metformin hydrochloride and polyvinilpyrolidone (PVP) mixing process, which is the first stage in the tablet ...
Marić Ljiljana B., Jović Branislav D., Petrović Slobodan D., Nikolić Aleksandar M., Homšek Irena J.   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pattern formation in a ring cavity with temporally incoherent feedback [PDF]

, 2004
We present a theoretical and experimental study of modulation instability and pattern formation in a passive nonlinear optical cavity that is longer than the coherence length of the light circulating in it.
Buljan, Hrvjoe, Carmon, Tal, Cohen, Oren, Fleischer, Jason W., Schwartz, Tal, Segev, Mordechai   +5 more
core   +1 more source