Results 61 to 70 of about 128,853 (246)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Aplicación de métodos matemáticos y estadísticos en la industria The application of mathematical and statistical methods in industry

Revista Técnica de la Facultad de Ingeniería, 2010
La Quimiometría ha sido definida como “la disciplina que utiliza métodos matemáticos y estadísticos para seleccionar o diseñar procedimientos y experimentos óptimos, y proveer información relevante a partir de datos químicos”.
Carlos Alciaturi, Marcos Escobar, Iván Esteves, Zoilabet Duque   +3 more
doaj  

Process analytical technology tools for perfusion cell culture

Engineering in Life Sciences, 2016
During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen).
Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Neural Network-Based Kinetic Model for Antisolvent Crystallization of Benzophenone: Construction, Validation, and Mechanistic Interpretation

Crystals
The emergence of artificial neural networks and the widespread application of process analytical technology (PAT) have founded a robust foundation for neural network applications in crystallization research.
Yafei Dong, Shutian Xuanyuan, Chuang Xie, Ying Sun, Xiaomeng Zhou, Yuanhang Wang   +5 more
doaj   +1 more source

A BRIEF REVIEW ON PROCESS ANALYTICAL TECHNOLOGY (PAT) [PDF]

, 2016
Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes.
Jagtap, Monali, Karekar, P., Mali, Akash S., MARUSKA, A.   +3 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Using a Multiple-Case Studies Design to Investigate the Information-Seeking Behavior of Arts Administrators [PDF]

, 2006
The case study method, and in particular the multiple???case studies design, offers LIS researchers a proven tool for achieving a deep understanding of a specific phenomenon???-for example, the information- seeking behavior of a particular user group.
Zach, Lisl
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Towards a theoretical foundation of IT governance: the COBIT 5 case [PDF]

, 2015
: COBIT, (Control Objectives for Information and Information related Technologies) as an IT governance framework is well-known in IS practitioners communities. It would impair the virtues of COBIT to present it only as an IT governance framework.
Devos, Jan, Van De Ginste, Kevin
core