Results 61 to 70 of about 1,083,264 (224)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Transdermal iontophoresis patch with reverse electrodialysis

open access: yesDrug Delivery, 2017
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy.
Joon Lee   +5 more
doaj   +1 more source

Global analysis of a multi-group SIR epidemic model with nonlinear incidence rates and distributed moving delays between patches

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
In this paper, applying Lyapunov functional approach, we establish sufficient conditions under which each equilibrium is globally asymptotically stable for a class of multi-group SIR epidemic models.
Yoshiaki Muroya   +2 more
doaj   +1 more source

Central limit approximations for Markov population processes with countably many types [PDF]

open access: yes, 2012
When modelling metapopulation dynamics, the influence of a single patch on the metapopulation depends on the number of individuals in the patch. Since there is usually no obvious natural upper limit on the number of individuals in a patch, this leads to ...
Barbour, A. D., Luczak, M. J.
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

A Color Multi-Exposure Image Fusion Approach Using Structural Patch Decomposition

open access: yesIEEE Access, 2018
A novel color multi-exposure image fusion approach is proposed to solve the problem of the loss of visual details and vivid colors. The proposed method is based on an image patch that is decomposed into three different independent parts: contrast ...
Fan Huang   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Observing Custom Software Modifications: A Quantitative Approach of Tracking the Evolution of Patch Stacks

open access: yes, 2016
Modifications to open-source software (OSS) are often provided in the form of "patch stacks" - sets of changes (patches) that modify a given body of source code.
Lohmann, Daniel   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Dual-Mode Microstrip Patch Bandpass Filters With Generalized Frequency Responses

open access: yesIEEE Access, 2019
A basic two-pole bandpass filter based on the dual-mode square patch resonator is presented and analyzed to realize generalized frequency responses in terms of two finite transmission zeros (FTZs).
Qing Liu   +4 more
doaj   +1 more source

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