Results 61 to 70 of about 741,076 (339)

Image patch analysis and clustering of sunspots: a dimensionality reduction approach

open access: yes, 2014
Sunspots, as seen in white light or continuum images, are associated with regions of high magnetic activity on the Sun, visible on magnetogram images. Their complexity is correlated with explosive solar activity and so classifying these active regions is
Delouille, Veronique   +4 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Study on Casing Patch Technology of Large Diameter Expandable Thin-walled Tubular for Casing Damaged Well

open access: yesShiyou jixie, 2017
The use of low-alloy material thin-walled tubular for casing patch could obtain a larger diameter than the conventional expandable casing patch system. On the basis of the material selection requirements of the thin-walled patch tubular, the structure of
Wang Hai   +4 more
doaj  

Image patch analysis of sunspots and active regions. I. Intrinsic dimension and correlation analysis

open access: yes, 2015
The flare-productivity of an active region is observed to be related to its spatial complexity. Mount Wilson or McIntosh sunspot classifications measure such complexity but in a categorical way, and may therefore not use all the information present in ...
De Visscher, Ruben   +5 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Pharmacodynamic analysis of the analgesic effect of capsaicin 8% patch (QutenzaTM) in diabetic neuropathic pain patients: detection of distinct response groups

open access: yesJournal of Pain Research, 2012
Christian Martini1,*, Ashraf Yassen2,*, Erik Olofsen1, Paul Passier2, Malcom Stoker3, Albert Dahan1 1Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands; 2Global Clinical Pharmacology and Exploratory Development ...
Martini C   +5 more
doaj  

Robust approximation error estimates and multigrid solvers for isogeometric multi-patch discretizations

open access: yes, 2018
In recent publications, the author and his coworkers have shown robust approximation error estimates for B-splines of maximum smoothness and have proposed multigrid methods based on them.
Takacs, Stefan
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Effectiveness and Safety of Different Patch Materials for Supravalvar Aortic Stenosis (Middle-Term Outcomes)

open access: yesReviews in Cardiovascular Medicine
Background: To determine the effectiveness and safety of different patch materials in the treatment of pediatric patients with congenital supravalvular aortic stenosis (SVAS). Methods: 218 consecutive SVAS patients (age
Xinyue Lang   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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