Results 81 to 90 of about 740,828 (291)

Synthesis versus analysis in patch-based image priors

open access: yes, 2017
In global models/priors (for example, using wavelet frames), there is a well known analysis vs synthesis dichotomy in the way signal/image priors are formulated. In patch-based image models/priors, this dichotomy is also present in the choice of how each
Figueiredo, Mario A. T.
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding

open access: yesClinicoEconomics and Outcomes Research, 2016
Mitra Corral,1 Nicole Ferko,2 Andrew Hogan,2 Sarah S Hollmann,2 Gaurav Gangoli,1 Nadine Jamous,3 Jonathan Batiller,1 Richard Kocharian1 1Ethicon BioSurgery, Somerville, NJ, USA; 2Cornerstone Research Group, Burlington, ON, Canada; 3Ethicon Biosurgery ...
Corral M   +7 more
doaj  

Isogeometric B\'ezier dual mortaring: Refineable higher-order spline dual bases and weakly continuous geometry

open access: yes, 2017
In this paper we develop the isogeometric B\'ezier dual mortar method. It is based on B\'ezier extraction and projection and is applicable to any spline space which can be represented in B\'ezier form (i.e., NURBS, T-splines, LR-splines, etc.).
Borden, M. J.   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Experimental Study on Influence of Different Patterns of an Emergent Vegetation Patch on the Flow Field and Scour/Deposition Processes in the Wake Region

open access: yesWater Resources Research
Flume experiments were conducted to comprehend the impact of different patterns of an emergent vegetation patch on the flow field and the scour process in natural rivers.
Oral Yagci   +5 more
doaj   +1 more source

Efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on activities of daily living in severe Alzheimer’s disease

open access: yesSAGE Open Medicine, 2014
Objective: Investigate efficacy of 13.3 mg/24 h rivastigmine patch in patients with severe Alzheimer’s disease on Alzheimer’s Disease Cooperative Study–Activities of Daily Living Scale–Severe Impairment Version items and domains.
Joseph L Micca   +3 more
doaj   +1 more source

Unstructured spline spaces for isogeometric analysis based on spline manifolds

open access: yes, 2015
Based on spline manifolds we introduce and study a mathematical framework for analysis-suitable unstructured B-spline spaces. In this setting the parameter domain has a manifold structure, which allows for the definition of function spaces that have a ...
Sangalli, Giancarlo   +2 more
core   +1 more source

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