Results 31 to 40 of about 522 (215)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pipeline repair by composite patch under temperature and pressure loading

Fracture and Structural Integrity, 2019
In this study, the three-dimensional finite element method is used to analyze an API 5L X70 steel cylindrical pipeline subjected to an internal pressure load by calculating the stress intensity factors and the integral J at the peak of crack in elastic ...
E. Abdelouahed, H. Benzaama, M. Mokhtari, B. Aour   +3 more
doaj   +3 more sources

A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery

Gels, 2022
Recently, phenylboronic acid (PBA) gel containing microneedle (MN) technology with acute and sustained glucose-sensitive functionality has attracted significant research attention.
Siyuan Chen, Takuya Miyazaki, Michiko Itoh, Hiroko Matsumoto, Yuki Moro-oka, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami, Akira Matsumoto   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch [PDF]

Journal of Controlled Release
Parkinson's disease (PD), affecting about ten million people globally, presents a significant health challenge. Rotigotine (RTG), a dopamine agonist, is currently administered as a transdermal patch (Neupro®) for PD treatment, but the daily application can be burdensome and cause skin irritation.
Li, Yaocun, Wang, Jiawen, Vora, Lalitkumar K., Sabri, Akmal Hidayat Bin, McGuckin, Mary B., Paredes, Alejandro J., Donnelly, Ryan F.   +6 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Circularly Polarized Patch Antenna for Future 5G Mobile Phones

IEEE Access, 2014
A circularly polarized patch antenna for future fifth-generation mobile phones is presented in this paper. Miniaturization and beamwidth enhancement of a patch antenna are the two main areas to be discussed.
Ka Ming Mak, Hau Wah Lai, Kwai Man Luk, Chi Hou Chan   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study

Applications in Engineering Science
This study introduces an experimentally-calibrated finite-element framework to predict the endovascular sealing performance of a bioresorbable patch for aortic dissection repair.
Marta I. Bracco, Francesc Canalejo-Codina, Agustina Giuliodori, Andrea Montanino, Alejandro Aranda, Jordi Martorell, Eduardo Soudah   +6 more
doaj   +1 more source

Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery

Journal of Functional Biomaterials, 2023
Clarithromycin (CLR), categorized as a Biopharmaceutical Classification System class II drug, has several gastrointestinal tract side effects and an extremely unpalatable bitter taste.
Ahlam Zaid Alkilani, Batool Musleh, Rania Hamed, Lubna Swellmeen, Haneen A. Basheer   +4 more
doaj   +1 more source