Results 41 to 50 of about 522 (215)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design of slit loaded Planar and Curved Patch Antenna

International Journal of Innovative Science and Modern Engineering, 2019
Slit loaded circularly polarized patch antenna embedded on planar structure and curvature structure were investigated. The curvature effect on slit loaded patch antenna determines the limiting value of radius of curvature to obtain circular polarization.
Sumanta Kumar Kundu, Pramod Kumar Singhal   +1 more
openaire   +2 more sources

Bandwidth-Enhanced Circularly Polarized Crescent-Shaped Slot Antenna via Circular-Patch Loading

Applied Sciences, 2019
This paper presents the crescent-shaped slot antenna loading of a circular patch that greatly enhances a 3 dB axial-ratio (AR) bandwidth. A bent feeding line was introduced and attached to a 50- Ω microstrip feed line to achieve circular ...
Son Trinh-Van, Youngoo Yang, Kang-Yoon Lee, Yong Serk Kim, Keum Cheol Hwang   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Fishnet based metamaterial loaded THz patch antenna

Optical and Quantum Electronics, 2016
A fishnet based metamaterial (MTM) loaded rectangular microstrip patch antenna (RMPA) is proposed for THz applications. The negative refractive index of the MTM has been displayed at frequency range between 1.05 and 1.1 THz. This MTM can be used for improving the return loss, gain and radiation efficiency of RMPA.
Sirmaci, Y. Denizhan, Akin, Cagdas K., Sabah, Cumali   +2 more
openaire   +2 more sources

Comparative Analysis of Active Bonded Piezoelectric Repair Systems for Damaged Structures under Mechanical and Thermo-Mechanical Loads

Actuators
Active repair systems employing piezoelectric (PZT) patches have emerged as promising solutions for mitigating crack propagation and enhancing structural integrity in various engineering applications.
Mohammed Abdulla, Meftah Hrairi, Abdul Aabid, Nur Azam Abdullah, Muneer Baig   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

A self‐adhesive microneedle patch with drug loading capability through swelling effect

Bioengineering & Translational Medicine, 2020
Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug.
Sharon W. T. Chew, Ankur H. Shah, Mengjia Zheng, Hao Chang, Christian Wiraja, Terry W. J. Steele, Chenjie Xu   +6 more
doaj   +1 more source