Results 61 to 70 of about 522 (215)

Fatigue crack growth of composite patch repaired Al-alloy plates under variable amplitude loading

Fracture and Structural Integrity, 2017
In this paper, fatigue crack growth of edge crack in 2024 T351 aluminum alloy plate repaired with bonded composite patch under constant and variable amplitude loading (VAL) was predicted. The Al-alloy plate was repaired with symmetric patch “Boron/Epoxy”.
Fatima Zohra Seriari, Mustapha Benachour, Mohamed Benguediab   +2 more
doaj  

Core–Shell Silk Fibroin Hydrogel Microneedles Functionalized with Antibody-Binding Domains for Transdermal Delivery

Biomimetics
Microneedle (MN) patches comprise a promising platform for transdermal delivery of macromolecular therapeutics. However, achieving sufficient mechanical strength for skin penetration while maintaining high biocompatibility and efficient antibody loading ...
Min Ki Lee, Ae Sol Lee, Chang Sup Kim
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Miniaturized Patch Antenna by Using a CSRR Loading Plane

International Journal of Antennas and Propagation, 2015
This paper presents a design methodology for the implementation of a miniaturized square patch antenna and its circuit model for 5.15 GHz ISM band.
Mehrab Ramzan, Kagan Topalli
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Wideband patch antenna through introducing co‐plane terminal

IET Microwaves, Antennas & Propagation
Wideband operation is a crucial topic in patch structure research. Various wideband methods have been developed for patch antennas. However, some of the key benefits of patch antennas, such as semi‐space radiation and easy fabrication, are degraded.
Boyu Sima, Zhengkun Guo, Run Liu, Heling Gong, Qingqing Yang, Jun Hu, Zhiwei Sun, Wen Wu   +7 more
doaj   +1 more source

Resonance of High Tc Superconducting Microstrip Patch in a Substrate-Superstrate Configuration

Advanced Electromagnetics, 2014
The effect of a protecting dielectric superstrate on the resonance of a high Tc superconducting microstrip patch is investigated. The analysis approach is based on the spectral-domain method of moments in conjunction with the complex resistive boundary ...
S. Benkouda, T. Fortaki, M. Amir, A. Benghalia   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

pH/NIR dual-responsive implantable patch for combined photothermal and chemotherapy of tumors

International Journal of Pharmaceutics: X
The treatment of malignant solid tumors still faces challenges including the high risk of surgical resection and the severe side effects of chemotherapy.
Wenjie Sun, Xi Zhang, Yili Zhao, Bixiang Ye, Wen Gao, Guangyi Jiang, Xin Li, Xiaoji Lin   +7 more
doaj   +1 more source