Results 81 to 90 of about 114,808 (300)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Proposal for a revised international standard series of patch tests

, 1997
Worldwide, there are 3 major standard series of patch tests, the European, North American and Japanese, together presenting 32 allergens, the differences between them being the result of regional variation in allergen distribution as well as differences ...
Frosch, P.J., Hannuksela, M., Hayakawa, R., Lachapelle, Jean-Marie, Wahlberg, J.E., Ale, S.I., Goh, C.L., Freeman, S., Maibach, H.I.   +8 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Epidemiological Study of Periocular Dermatitis in a Specialised Hospital Department

Iranian Journal of Allergy, Asthma and Immunology, 2011
Contact dermatitis is frequent skin pathology and eyelids are one of the more frequent locations of this pathology. The objective of the present work was to study the population distribution of periocular dermatitis, determine the allergens which most ...
Rafael Rojo-España, Lidia Tomas-Mallebrera, Natalia Gimeno-Clemente, Amparo Marquina-Vila, María Morales-Suárez-Varela   +4 more
doaj  

Diagnostics of cutaneous adverse drug reactions: evaluation of patch tests, lymphocyte transformation tests, and drug provocation tests

Journal of Cutaneous Immunology and Allergy
BackgroundPatch tests (PT) and/or lymphocyte transformation tests (LTT) are typically performed, when diagnosed with cutaneous adverse drug reactions (CADR). However, their positivity rates can vary depending on the rash type.
Tomomu Ishikawa, Risa Tamagawa-Mineoka, Risa Tamagawa-Mineoka, Koji Masuda, Norito Katoh, Takeshi Fukumoto   +5 more
doaj   +1 more source

Stamping a case of cutaneous adverse drug reaction: Proving beyond causality assessment

Indian Journal of Dermatology, 2018
Different types of skin testing with a suspected drug have been reported to be helpful in determining the cause of cutaneous adverse drug reactions (CADRs).
Sudip Das, Projna Biswas, Dayamay Pal, Abhishek De   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Acute generalized exanthematous pustulosis induced by ceftriaxone with positive patch testing

Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous reaction. In over 90% of patients it is an adverse reaction to drugs. Delayed-type (type IV) hypersensitivity seems to play an important role in its pathophysiology.
Carmem Botelho, Lise Brosseron, Ana Gabriela Lopes   +2 more
core   +1 more source

Baboon syndrome induced by hydroxyzine

Indian Journal of Dermatology, 2013
Hydroxyzine-induced drug eruptions are very rare. We report here a typical case of drug-related Baboon syndrome or symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) which was induced by hydroxyzine in a 60-year-old man.
Hayet Akkari, Hichem Belhadjali, Monia Youssef, Sana Mokni, Jamelediine Zili   +4 more
doaj   +1 more source