Results 21 to 30 of about 35,849 (293)

White and Brown Patched Texas Longhorn

, 1982
White and Brown Patched Texas Longhorn standing at the edge of the ...

core   +3 more sources

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

eLife, 2016
The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor,
David S Lorberbaum, Andrea I Ramos, Kevin A Peterson, Brandon S Carpenter, David S Parker, Sandip De, Lauren E Hillers, Victoria M Blake, Yuichi Nishi, Matthew R McFarlane, Ason CY Chiang, Judith A Kassis, Benjamin L Allen, Andrew P McMahon, Scott Barolo   +14 more
doaj   +1 more source

Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity

Biomedicines, 2020
Adrenocortical carcinoma (ACC) presents a high risk of relapse and metastases with outcomes not improving despite extensive research and new targeted therapies.
Anida Hasanovic, Méliné Simsir, Frank S. Choveau, Enzo Lalli, Isabelle Mus-Veteau   +4 more
doaj   +1 more source

Developmental Status: Impact of Short-Term Ischemia on Follicular Survival of Whole Ovarian Transplantation in a Rabbit Model. [PDF]

PLoS ONE, 2015
Ischemia is the first mechanism that provokes the loss of follicles in ovarian grafts over the long term. In whole ovarian transplantation, it remains unknown, however, how changes in follicular development are influenced by short-term ischemia.
Shuangshuang Xie, Xing Zhang, Wenming Chen, Chichi Xie, Wenwei Chen, Pu Cheng, Ying Zhou, Bicheng Chen   +7 more
doaj   +1 more source

A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor

Journal of Developmental Biology
During their biosynthesis, Sonic hedgehog (Shh) morphogens are covalently modified by cholesterol at the C-terminus and palmitate at the N-terminus.
Sophia F. Ehlers, Dominique Manikowski, Georg Steffes, Kristina Ehring, Fabian Gude, Kay Grobe   +5 more
doaj   +1 more source

Ally patches for spoliation of adversarial patches [PDF]

Journal of Big Data, 2019
تمثل الهجمات العدائية تهديدًا خطيرًا متطورًا لتشغيل الشبكات العصبية العميقة. في الآونة الأخيرة، تم تطوير خوارزميات الخصومة لتسهيل هلوسة الشبكات العصبية العميقة للمهاجمين العاديين. يمكن للخوارزميات الحديثة أن تولد بقعًا عدائية قابلة للطباعة دون اتصال بالإنترنت يمكن أن تتخللها مجالات رؤية الكاميرات الملتقطة في إجراء غير ملحوظ ببراءة. في هذه الورقة، نقترح
openaire   +3 more sources

PTCH1 (patched homolog 1 (Drosophila)) [PDF]

, 1999
Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cory House 195: Window Patched, Second Floor, East

, 2021
Window patched on the second floor, east.https://docs.rwu.edu/baker_images/1302/thumbnail ...

core   +2 more sources