Results 41 to 50 of about 35,849 (293)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
IEEE Transactions on Fuzzy Systems, 2020 There have been different strategies to improve the performance of a machine learning model, e.g., increasing the depth, width, and/or nonlinearity of the model, and using ensemble learning to aggregate multiple base/weak learners in parallel or in series. This paper proposes a novel strategy called patch learning (PL) for this problem.
Dongrui Wu, Jerry M. Mendel
openaire +2 more sources
Road performance of cold repaired asphalt mixture with new green maintenance materials
Case Studies in Construction MaterialsCold patched asphalt mixture plays a crucial role in road maintenance, providing flexibility and the ability to quickly recover from harsh weather conditions.
Tao Wang +9 more
doaj +1 more source
PTCH1 (patched homolog 1 (Drosophila))
, 2001 Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Lindstr
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
S-patch: Modification of the Hermite parametric patch
CoRR, 2010 A new modification of the Hermite cubic rectangular patch is proposed: the S-Patch, which is based on the requirement that diagonal curves must be of degree 3 instead of degree 6 as it is in the case of the Hermite patch. Theoretical derivation of conditions is presented and some experimental results as well. The S-Patch is convenient for applications,
Skala, Václav, Ondračka, Vít
openaire +4 more sources
Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases
Frontiers in Medicine, 2022 BackgroundThis study qualitatively and quantitatively compared imaging characteristics between neovascular and atrophic pachychoroid spectrum disease (PSD) by optical coherence tomography (OCT), and OCT angiography (OCTA).MethodsThe subtypes of PSD were ...
Rui Hua +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source