Results 51 to 60 of about 67,991 (291)

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Over Half of Patients Progress to Cartilage Restoration After Initial Cartilage Biopsy in a Military Population. [PDF]

Arthrosc Sports Med Rehabil
Purpose To evaluate the rate of matrix‐induced autologous chondrocyte implantation (MACI) after cartilage biopsy in a military population. Methods A retrospective review was conducted of all patients who underwent a cartilage biopsy at 2 large regional military health centers between January 2021 and May 2023.
Sanborn RM, Pluta NA, Fellows KJ, Cruz CA, Patzkowski JC, Cognetti DJ.   +5 more
europepmc   +2 more sources

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Lower Limb Biomechanical Variables Are Indicators of the Pattern of Presentation of Patella Tendinopathy in Elite African Basketball and Volleyball Players [PDF]

Revista Brasileira de Ortopedia, 2019
Objective The present study determined the pattern of presentation and severity of patellar tendinopathy (PT) and its relationship with selected biomechanical variables in elite athletes.
Ayoola Aiyegbusi, Bidemi Tella, Chukwuebuka Okeke   +2 more
doaj   +3 more sources

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Pseudochondromalacia Patellae [PDF]

Acta Orthopaedica Scandinavica, 1978
A condition causing knee pain with retropatellar crepitus similar to chondromalacia patellae is described. The symptoms seem to be due not to chondromalacia of the patella, but to a local synovial thickening proximal to the articular surface of the medial femoral condyle.
openaire   +2 more sources

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

Patellar Giant-Cell Tumor: a Case Report

Journal of Experimental Life Science, 2018
Giant cell tumor (GCT) found mostly in the long bones metaphysis or epiphysis. GCT usually occur between the ages of a third and fourth decade and locally aggressive. Giant-Cell Tumor seldom affects the patella. Multicentric forms rarely reported.
Istan Irmansyah Irsan, Satria Pandu Persada, Rakhmad Aditya   +2 more
doaj   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source