Results 61 to 70 of about 72,680 (294)
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
JAMA: The Journal of the American Medical Association, 1899 Fractures of the patella are not of frequent occurrence; they constitute about 2 per cent, of all fractures, and are found more frequently in the male than in the female—in the proportion of about five to one. Fractures of this bone demand careful consideration, on account of its close proximity to the knee-joint, and also in consequence of the ...
openaire +1 more source
Advanced Science, EarlyView.Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou +15 more
wiley +1 more source
Fr. Michael Patella, OSB - Witness
, 2013 Join Fr. Thomas Rosica, CSB for this Witness interview with Fr. Michael Patella, OSB, a Benedictine monk of Saint John\u27s Abbey in Collegeville, Minnesota and a professor of New Testament at the Saint John\u27s School of Theology-Seminary.
Patella, Michael, OSB +1 more
core +1 more source
A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery
Advanced Science, EarlyView.A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu +16 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.For musculoskeletal robots, this study proposes a purely mechanical reflex module. Specifically, this module implements a length feedback mechanism without electronics, enabling autonomous contraction of an artificial muscle once its length exceeds a threshold.
Shunsuke Koseki +2 more
wiley +1 more source
European Journal of Human Genetics, 2019 We review genetic diseases with identified molecular bases that include abnormal, reduced (hypoplasia), or absent (aplasia) patellae as a significant aspect of the phenotype. The known causal genes can be broadly organized according to three major developmental and cellular processes, although some genes may act in more than one of these: limb ...
Mark E. Samuels, Philippe M. Campeau
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Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Progressive pseudorheumatoid arthropathy of childhood (PPAC) is a rare autosomal recessive progressive condition that affects the cartilage of joints and bones. The symptoms of PPAC include stiffness of the joints, bony swelling of the toes and fingers, short stature, kyphosis, and muscle weakness.
Narinder Singh +5 more
wiley +1 more source