Results 181 to 190 of about 1,441,892 (337)

Innovations in Social Informatic: A Patent Landscape Review

Nur Afia, Agung Purnomo, Fairuz Iqbal Maulana, Yogi Tri Prasetyo, Ma. Janice J. Gumasing, Elsa Rosyidah, Satria Fadil Persada   +6 more
openalex   +1 more source

Patent Portfolio Races in Concentrated Markets for Technology [PDF]

Patent application numbers grow exponentially in many industries, a phenomenon that has been linked to high fragmentation of patent ownership. Contradicting these findings and theoretical arguments, we show that such fragmentation is not a precondition ...
Florian Jell, Joachim Henkel
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Characteristics of the Stem Cell Intellectual Property Rights and Patent Status: Focusing on Papers and Clinical Trials. [PDF]

Dev Reprod
Kim GJ, Kim Y, Shin WJ, Jeon Y.
europepmc   +1 more source

Competitive disadvantage through non-existing software patents [PDF]

In a model of sequential patent races, it is examined whether or not introducing a patent law in the home country is beneficial to the firms and the society as a whole given the foreign country already offers patent protection.
Pia Weiss
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Policy barriers to drug repurposing in Europe: different stakeholder perspectives identified during survey-based shortlisting of key challenges. [PDF]

Health Policy Open
Gyöngyösi K, Petykó ZI, Hosszú D, Pantziarka P, van der Meer HG, Lo DC, Csanádi M, Obeng GD, Kaló Z, Inotai A.   +9 more
europepmc   +1 more source

Social and Technological Efficiency of Patent Systems [PDF]

This article develops an evolutionary model of industry dynamics in order to carry out a richer theoretical analysis of the consequences of a stronger patent system.
Murat YILDIZOGLU (E3i, IFReDE-GRES), Thomas VALLEE (LEN-C3E)   +1 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Marching toward 100% whole genome sequencing

Frontiers in Genetics, 2016
Yih-Horng eShiao
doaj   +1 more source