Results 191 to 200 of about 1,441,892 (337)

Analysis of intellectual property strategies across different categories of digital therapeutics. [PDF]

Front Digit Health
Maeda T, Suzuki H, Saotome C.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mapping the TNFR2-targeting antibody patent landscape: Insights from macro trends to structural signatures. [PDF]

Hum Vaccin Immunother
Chen S, Chen Y, Zhang Y, Yao G, Cai H, Chen X, Hu Y.   +6 more
europepmc   +1 more source

Patente / Patents

Applied Rheology, 1996
openaire   +2 more sources

Propensity to Patent Brazilian Companies: importance of Economic and Financial Performance

, 2019
Patrícia Brandão Barbosa da Silva, Renata Silva-Man, Cristiano da Silva Santos   +2 more
openalex   +1 more source

Patent foramen ovale closure in non-lacunar cryptogenic ischemic stroke: where are we now?

, 2021
Adrià Arboix, Olga Parra, Josefina Alió   +2 more
openalex   +2 more sources

Endogenous R&D and Intellectual Property Laws in Developed and Emerging Economies [PDF]

The incentive of providing protection of intellectual property has been analyzed, both for an emerging economy as well as for a developed economy. The optimal patent length and the optimal patent breadth within a country are found to be positively ...
Bagchi, Aniruddha, Roy, Abhra
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Design strategies for flexible core biopsy needles: insights from patent literature. [PDF]

Front Med Technol
Ansems NM, Vasilic D, Breedveld P.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source