Results 81 to 90 of about 1,660,326 (362)
New England Journal of Medicine, 2001 BACKGROUND Patent foramen ovale and atrial septal aneurysm have been identified as potential risk factors for stroke, but information about their effect on the risk of recurrent stroke is limited.
J. Mas +6 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Simple vs. sophisticated approaches for patent prior-art search [PDF]
, 2011 Patent prior-art search is concerned with finding all filed patents relevant to a given patent application. We report a comparison between two search approaches representing the state-of-the-art in patent prior-art search.
Jones, Gareth J.F. +2 more
core
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Loser Pays in Patent Examination [PDF]
, 2016 Many scholars and practitioners believe there are too many “weak” patents—those that should not have issued but somehow get approved by the U.S. Patent and Trademark Office (PTO).
Sukhatme, Neel U.
core +1 more source
Patent Analytics Based on Feature Vector Space Model: A Case of IoT
, 2019 The number of approved patents worldwide increases rapidly each year, which requires new patent analytics to efficiently mine the valuable information attached to these patents.
Lei, Lei, Qi, Jiaju, Zheng, Kan
core +1 more source
Licensing Complementary Patents: “Patent Trolls”, Market Structure, and “Excessive” Royalties [PDF]
, 2009 The infamous Blackberry case brought new attention to so-called “patent trolls” and began the general association of trolls with “non-practicing” patent holders.
Layne-Farrar, Anne, Schmidt, Klaus M.
core +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
New England Journal of Medicine, 2013 BACKGROUND Whether closure of a patent foramen ovale is effective in the prevention of recurrent ischemic stroke in patients who have had a cryptogenic stroke is unknown.
J. Carroll +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source