Results 61 to 70 of about 22,625,188 (286)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

The Patent Quality Control Process: Can We Afford An (Rationally) Ignorant Patent Office? [PDF]

, 2008
This paper considers patent granting as a two-tiered process, which consists of patent office examination (public enforcement) and court challenges (private enforcement).
Chiou, Jing-Yuan, Jing-yuan Chiou
core   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors

Biosensors
Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection.
Ahmed Fatimi, Fouad Damiri, Mohammed Berrada, Adina Magdalena Musuc   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Hotspots and Trends of Patented Technologies for Heavy Metal-Contaminated Soil Remediation: A Systematic Review

Agriculture
Heavy metal soil pollution severely threatens human health and food safety. This study used PRISMA to systematically review heavy metal-contaminated soil remediation patents in the Derwent Patent Database from 2003 to 2023.
Wenmin Luo, Guiting Mu, Xianliang Wu, Wei Qin, Yingying Liu   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Patent Mining Approach to Accurately Identifying Innovative Industrial Clusters Based on the Multivariate DBSCAN Algorithm

Systems
Innovative Industrial Clusters (IIC), characterized by geographical aggregation and technological collaboration among technology enterprises and institutions, serve as pivotal drivers of regional economic competitiveness and technological advancements ...
Siping Zeng, Ting Wang, Wenguang Lin, Zhizhen Chen, Renbin Xiao   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Research of the Patent Map of Harmonic Reducer

Jixie chuandong, 2017
By using IPC classification method and data collection,the patent information hiding in the technological field of the harmonic reducer is mined. The corresponding patent map is drawn,the issues related to research harmonic reducer technology in the ...
Chen Zhilan, Chen Wei
doaj