Results 91 to 100 of about 773,443 (250)

圖書資訊相關系所的專利課程規劃與設計 The Patent Curriculum Planning and Design in Library and Information Science Schools [PDF]

open access: yesJiàoyù zīliào yǔ túshūguǎn xué, 2008
專利是公司創新研發投入的績效指標之一,亦可提供國家競爭力的參考資訊。由圖書館或資訊中心提供積極性的專利資訊服務的角度出發,本文提出圖書資訊系所專利相關課程的規劃與設計。首先,說明專利資訊及其資訊需求的特色,以及整理台灣地區學術界與產業界開設專利課程的概況。其次,分析圖書資訊系所開設專利課程的一系列由淺入深,由廣而專精的課程規劃。此外,針對圖書資訊專業提供專利檢索服務的SWOT分析,並提供專利檢索種子人才教育的數點建議。Patents are one of the important indicators
Yuan-Ho Huang
doaj  

Exploring Patent Passage Retrieval Using Nouns Phrases

open access: yes, 2013
This paper presents experiments which initially were carried out for the Patent Passage Retrieval track of CLEF-IP 2012. The Passage Retrieval module was implemented independently of the Document Retrieval system.
Andersson, Linda   +7 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Clopidogrel Nonresponsiveness Mimicking Endocarditis After PFO-Occlusion: Combining Aspiration, Retrieval, and Laboratory Assessment for Diagnostic-Therapeutic Work-Up

open access: yesAnnals of Internal Medicine: Clinical Cases
Percutaneous patent foramen ovale (PFO) closure lowers recurrent stroke risk but can rarely cause device thrombosis or infection. A 57-year-old woman had elective PFO closure with a GORE CARDIOFORM Septal Occluder device after cerebellar infarction ...
Omar Hajji   +4 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

open access: yesFEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Research on Chinese patent classification based on structured features

open access: yesScientific Reports
The three dimensions of Function, Structure, and Purpose are fundamental to patent classification and play a decisive role in improving the accuracy of patent information categorization. By providing targeted abstracts for each of these three dimensions,
Ran Li, Wangke Yu, Shuhua Wang
doaj   +1 more source

Retrieval Models Versus Retrievability

open access: yes, 2017
Retrievability is an important measure in information retrieval that can be used to analyze retrieval models and document collections. Rather than just focusing on a set of few documents that are given in the form of rel- evance judgments ...
Rauber, Andreas, Bashir, Shariq
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

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