Results 71 to 80 of about 773,443 (250)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Prozessorientierte Visualisierung im Patent-Retrieval
, 2019 In der Informationswissenschaft nimmt der Benutzer eine entscheidende Position bei der Erforschung neuer Ansätze ein. Aus diesem Grund stehen in dieser Dissertation Patent Information Professionals, die Nutzer von Patent-Retrieval-Systemen, im ...
Jürgens, Julia Judith
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Rescrewing the embolized duct occluder using the delivery cable
Annals of Pediatric Cardiology, 2014 We report the successful re-screwing of the embolized duct occluder (DO) in three children for retrieval and to attempt redeployment. The DO was embolized into descending aorta immediately after the deployment in one child and within 24 h after the ...
Nageswara Rao Koneti +3 more
doaj +1 more source
Distributed Patent Retrieval System Based on Nutch
, 2009 Along with the great flourish in world trade, patent is becoming increasingly important for protecting intellectual property. Although there are many patent retrieval systems for patent information searching, most of them, especially Chinese patent ...
Jun Ge +3 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Webis Patent Retrieval Corpus 2012 (Webis-PRA-12)
, 2012 <p>The Webis Patent Retrieval Corpus 2012 (Webis-PRA-12) is a corpus for studying the impact of misspelled companies on patent retrieval.</p> <p>The corpus contains 14,189 different company names extracted on the basis of 2,132,825 ...
Stein, Benno (5169011) +5 more
core +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
A new metric for patent retrieval evaluation [PDF]
, 2010 Patent retrieval is generally considered to be a recall-oriented information retrieval task that is growing in importance. Despite this fact, precision based scores such as mean average precision (MAP) remain the primary evaluation measures for patent ...
Magdy, Walid, Jones, Gareth J.F.
core +2 more sources