Results 61 to 70 of about 773,443 (250)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Patent information retrieval in the preparation of pharmacopeia articles on drugs projects

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article covers the issues of patent information retrieval technologies for the elaboration of draft pharmacopoeia monographs on immunobiologicals. It describes the opportunities of automated search in the databases of the Russian Federal Agency for ...
A. A. Elapov, T. M. Kargina, V. A. Merkulov   +2 more
doaj  

A New AS/RS Crane Design and Position Control in the Designed Crane to Increase Production Efficiency in Storage Systems

Machines
Automatic storage and retrieval systems (AS/RSs) are essential components of modern high-tech production facilities. This study presents the dynamic model and control of an innovative multi-platform automated storage crane system.
Erdi Yıldız, İkbal Eski
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Patent analysis provides insights into the history of cotton molecular breeding worldwide over the last 50 years

Journal of Integrative Agriculture, 2019
Cotton is a globally important natural fiber and oilseed crop of crucial economic significance. Molecular breeding has become a dominant method of cotton cultivation because it allows for a shorter breeding period and directional selection of high ...
Wei HE, Hui-min ZHAO, Xiao-wei YANG, Rui ZHANG, Jing-jing WANG   +4 more
doaj   +1 more source

Patent Retrieval in Chemistry based on semantically tagged Named Entities [PDF]

, 2009
Gurulingappa H, Müller B, Klinger R, et al. Patent Retrieval in Chemistry based on semantically tagged Named Entities. In: Voorhees EM, Buckland LP, eds. The Eighteenth Text RETrieval Conference (TREC 2009) Proceedings. Gaithersburg, Maryland, USA; 2009.
Klinger, Roman, Voorhees, Ellen M., Mevissen, Heinz-Theo, Hofmann-Apitius, Martin, Gurulingappa, H., Mevissen, H.-T., Hofmann-Apitius, M., Müller, B., Gurulingappa, Harsha, Müller, Bernd, Friedrich, Christoph M., Fluck, J., Fluck, Juliane, Buckland, Lori P., Klinger, R., Friedrich, C.M., Müller, Bernd Hans   +16 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Exploratory Patent Search with Faceted Search and Configurable Entity Mining [PDF]

, 2013
Searching for patents is usually a recall-oriented problem and depending on the patent search type, quite often a problem which is characterized by uncertainty and evolution or change of the information need. We propose an exploratory strategy for patent
Pavlos Fafalios, Salampasis, Michail, Michail Salampasis, Yannis Tzitzikas, Tzitzikas, Yannis, Fafalios, Pavlos   +5 more
core   +1 more source